Gestational diabetes associated with cardiovascular disease risk


A new study published in the  JAMA Internal Medicine , reported that gestational diabetes linked to increased risk of cardiovascular disease in females. The absolute rate of cardiovascular disease was less in the study's younger group of predominantly white females and a healthy lifestyle might lessen the risk.

History of gestational diabetes associated with cardiovascular disease risk in a large prospective cohort of US women, reported.

Gestational diabetes was impaired glucose tolerance in pregnancy. The American Heart Association on the basis of evidence for the association between gestational diabetes and cardio-metabolic risk markers identified gestational diabetes as a risk factor for cardiovascular disease in women.

Dr. Cuilin Zhang and his associates, in the Nurses' Health Study II, enrolled> 116,000 female nurses (age = 24-44years) and studied the history of gestational diabetes and risk of major cardiovascular disease events , such as heart attack and stroke. A history of gestational diabetes was captured on the baseline questionnaire and updated every two years through 2001; the primary study outcome of interest was a composite of nonfatal and fatal heart attack (myocardial infarction) and stroke occurring from baseline through the 2013 questionnaire.

The researchers reported that approximately 90,000 pregnant women were eligible for the analysis in the study. Nearly 5,300 women (5.9%) reported a history of gestational diabetes. The researchers found 1,161 pregnant females during nearly 26 years of follow-up reported new primary cardiovascular disease events including heart attacks (n = 612) and strokes (n = 553), the study authors said.

A modestly increased risk of cardiovascular disease was linked to a history of gestational diabetes when compared with females without gestational diabetes. But the absolute risk difference was less might be due to the younger age of the study group. The modestly increased risk of cardiovascular disease could be alleviated by adhering to a healthy lifestyle, including a healthful diet, physical activity, not smoking and not being overweight or obese, in subsequent years.

The study authors said that a racially/ethnically homogenous study population did not addressed the association between gestational diabetes and cardiovascular disease in potentially higher-risk minority populations was the drawback of the study.

The authors concluded that the prospective results of the study with continuous follow-up of the females were required.