NOTICIAS DIARIAS

GBS Vaccine: Cost-effective Way of Preventing Infant Deaths

Anaesthesiology

Bacteria which 1 in 10 pregnant women carry, and which can cause death or serious complications in their babies, could be targeted in a cost-effective way by a future vaccine – even if it costs the NHS as high as £54 a dose.

GBS disease, caused by Group B Streptococcus, is responsible for half of all meningitis cases in very young babies, and is a leading cause of sepsis – otherwise known as blood poisoning.

The UK's current GBS prevention strategy involves identifying at-risk expectant mothers and giving them antibiotics during childbirth, but GBS disease – although still rare – is becoming more common. And with several candidate vaccines for pregnant women now in development, health economists have been crunching numbers to see if immunization could be affordable for the NHS once a vaccine is licensed for use.

Dr. Kyriaki Giorgakoudi, Lecturer in Health Economics at Brunel University London, said: "Group B Streptococcus is part of the body's natural flora, and most of us who have it don't experience any adverse effects. But for young babies, GBS can be dangerous.

"GBS disease affects 1 in 1000 babies in the UK, which is nearly 750 babies every year, with more than 1 in 20 of these cases being fatal. Nearly half the survivors of GBS disease will have adverse long-term outcomes, with GBS causing lasting damage to their brain functions."

Modeling health outcomes versus costs

In the study, funded by the Meningitis Research Foundation and published in the journal Vaccine, the researchers used their model to explore different scenarios and identify when maternal immunization – expected to be used together with the current antibiotic strategy – would represent value for money.

"Cost-effectiveness in healthcare is about understanding the best we can do with the currently available financial resources, and how we can allocate these resources to get the most health benefits," Dr. Giorgakoudi said.

Immunization "the best way to save lives"

The excellent prospect of a vaccine reducing the burden on GBS disease is encouraging news for key organizations for whom neonatal meningitis reduction is an international priority, including the Meningitis Research Foundation.

Linda Glennie, Director of Research at Meningitis Research Foundation, said "Screening pregnant women for GBS is not routine in many countries, and while guidance exists to identify at-risk expectant mothers, it is not consistently delivered and cannot prevent all cases.

"GBS is still rising in the UK and beyond. Preventing GBS by vaccinating pregnant women would be the best way to save lives. We are delighted that the findings from this research could help speed up introduction of a vaccine once it is licenced to protect pregnant women and their newborn babies from GBS."

Dr. Giorgakoudi added: "We don't know exactly how many years in the future a vaccine will be ready to roll out. "But when it is, a maternal immunisation strategy in combination with the current antibiotic strategy is highly likely to be a cost-effective intervention against infant GBS disease for the NHS, assuming the vaccine is safe, effective, and can be purchased and administered at a reasonable price."