FUT2 Variants Confer Susceptibility to Familial Otitis Media


Researchers have found multiple genetic variants within the FUT2 gene that makes some people especially susceptible to middle ear infections. Middle ear infections are very common in kids. By the time they are 1-year-old around half of the fever, ear pain or pus/fluid in the middle ear due to infection.

Some of these infections may recur or become chronic thus requiring surgery. The FUT2 gene is expressed in the salivary gland, colon, and lungs but its expression in the middle ear has not been previously reported.

They discovered the role of the gene in the middle ear infections or otitis media by initially examining DNA samples from 609 multi-ethnic families with the condition. The found common variants of the gene in Filipinos and South Asians and to variant associated with recurrent middle ear infections in European-American children.

The most common variant occurs in 30-50% of individuals in almost all population groups except East Asians. A number of things predispose people to get these infections including a lack of vaccinations, lack of breastfeeding and being around smoking caregivers.

But even in the best case scenario, recurrent or chronic middle ear infections still happen in some kids, which may be due to genetic predisposition. Those who possessed the genetic variants had a much higher chance of getting the infection.

Middle Ear

The researchers believe the gene modifies the microbiome of the middle ear in a way that makes it more susceptible to infection by specific bacteria. If you have these mutations, you will have a slightly different microbiota which could raise the risk of disease.

The finding could eventually lead to new ways of determining who is likely to get the infection. The study confirmed the expression of FUT2 in the middle ear which is spiked within 24 hours of bacterial infection.

But the FUT2 genetic variants decrease presentation of Antigen used by bacteria to gain access to the middle ear lining. That causes a decrease in some bacteria while boosting the numbers of bacteria known to play a role in chronic or recurrent disease.

The frequency of population-specific FUT2 variants makes this gene a potential target for preventative screening and future treatments for otitis media, including modulation of the middle ear microbiome.