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Fragile X Imaging Study Reveals Differences in the Brains of Infant

Anaesthesiology

Researchers from the UNC School of Medicine used Magnetic Resonance Imaging (MRI) for the first time to show then anatomical changes that, over time, progressively differentiate the brains of children with fragile X syndrome from those of children without it.

Imaging various sections of white matter from different angles can help researchers focus on the underlying brain circuitry important for proper neuron communication. The study, published in JAMA Psychiatry, shows that there are brain differences related to the neurodevelopmental disorder established well before a diagnosis is typically made at age three or later.

"It's our hope that earlier diagnosis and intervention will help children with fragile X and their families," said co-first author Meghan Swanson, a postdoctoral research fellow at the Carolina Institute for Developmental Disabilities at the UNC School of Medicine. "We also hope that this knowledge might inform drug development research."

So far, drug clinical trials have failed to demonstrate the change in treatment targets in individuals with fragile X. One of the challenges has been identifying good treatment outcome measures or biomarkers that show the response to intervention.

Fragile X syndrome is a genetic disorder and the most common inherited cause of intellectual disability in males. Symptoms include intellectual disabilities, problems with social interaction, delayed speech, hyperactivity, repetitive behaviors, and speech. About 10% of people with fragile X experience seizures. 

"One of the exciting things about our findings is that the white matter differences we observe could be used as an objective marker for treatment effectiveness," said co-senior author Heather C. Hazlett, assistant professor of psychiatry at the UNC School of Medicine.

In the study, Swanson, Hazlett, and colleagues imaged the brains of 27 infants who went on to be diagnosed with fragile X and 73 who did not develop the condition. The researchers focused on 19 white matter fiber tracts in the brain. Fiber tracts are bundles of myelinated axons – the long parts of neurons that extend across the brain or throughout the nervous system.

Think of bundles of cables laid across the brain. These bundles of axons connect various parts of the brain so that neurons can rapidly communicate with each other. This communication is essential, especially for proper neurodevelopment during childhood.

Imaging and analytical analysis showed significant differences in the development of 12 of 19 fiber tracts in babies with fragile X from as early as six months of age. The babies who wound up being diagnosed with fragile X had significantly less-developed fiber tracts in various parts of the brain.

"These results substantiate what other researchers have shown in rodents – the essential role of fragile X gene expression on early development of white matter in babies," said co-first author Jason Wolff, assistant professor of educational psychology at the University of Minnesota.

"Our work highlights that white matter circuitry is a potentially promising and measurable target for early intervention. However, achieving the goal of infant intervention for fragile X would likely require expanded newborn screening efforts," Wolff concluded.