A targeted drug with potential to slow the progress of ovarian cancer has rejected for use on the NHS in England. In making its provisional decision on rucaparib (Rubraca); the National Institute of Health and Care Excellence (NICE) cited a lack of evidence over the treatment’s impact on survival. “NICE felt there was not enough evidence to be confident about the drug’s long-term benefits, and that the benefit it gave was not enough to justify its cost,” said Rose Gray; policy manager at Cancer Research UK.
NICE will review its decision in September before which Gray; urges further exploration of how to make the drug available to patients. Rucaparib kills cancer cells by blocking the activity of a molecule called PARP; which helps repair damage to DNA. The drug used as a maintenance treatment for adults with ovarian cancer.
Advanced ovarian cancer
It would be offered to patients whose disease already responded to platinum-based chemotherapy; preventing patients having to wait until their cancer relapses before additional treatment offer. Rucaparib used to help extend the time before the disease comes back and delay the need for further platinum-based chemotherapy. Importantly, this could reduce the chance that patients’ cancers; develop resistance to platinum-based treatment, after which there are few options available.
As well as advanced ovarian cancer, the decision will also impact some patients with gynaecological cancers of the fallopian tube; and the tissue layer covering the stomach (peritoneum). Gray said the decision would be disappointing for people affected by these types of cancers. “Clinical trial evidence suggests rucaparib; could give patients more time before their disease gets worse and delay the need for further treatment.”
Clinical trial results suggests rucaparib extends the time before cancer progresses to 10.8 months; compared with 5.4 months with routine care. But as long-term data from the trial are not yet available; too much uncertainty remains over exactly how much longer people may live after taking rucaparib.
In addition to this lack of information, cost-effectiveness estimates were higher than NICE typically considers acceptable. “NICE will review this decision next month, and we urge them, NHS England and the manufacturer to work together in that time to explore how the drug can be made available to NHS patients,” Gray added.
NICE decisions are usually adopt in Wales and Northern Ireland as well. Decisions about what drugs the NHS should fund in Scotland are made separately by the Scottish Medicines Consortium. Rucaparib is not the only PARP inhibitor tested for adults with ovarian and gynaecological cancers. Another drug, niraparib, which works in a similar way to rucaparib is available through the Cancer Drugs Fund for some patients who have had two or more previous courses of platinum-based chemotherapy. If approved, rucaparib could be an additional option for this group of patients.