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Medical Genetics

Genetic Mutations Promote Regeneration After Liver Damage

Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified genetic mutations that accumulate in the adult liver that can promote regeneration in the context of chronic liver damage. Researchers show that mutations in human livers can promote tissue regeneration. Healthy people The widespread use of genome sequencing has led to…

Nuclear medicine

Study Demonstrates Clinical Impact of Amyloid PET Imaging

Amyloid PET imaging is a diagnostic technique that determines whether patients with memory complaints have amyloid plaques in the brain, an indicator of Alzheimer’s disease. It represents a potential major advance in the assessment of those with cognitive impairment. Before amyloid PET, these plaques could only be detect by examining the brain at autopsy. Memory…

Pharmacology

Researchers Develop 'Nano Vehicle' To Deliver Life-Saving Drugs

Despite many successes, modern medicine is still struggling to find effective treatments for serious pathologies such as cancer and neurodegenerative and inflammatory diseases. For Alzheimer’s disease, for example, only 30% of patients respond to therapy whereas for cancers the figure is only 25%. ‘The real bottleneck is not the absence of an efficient drug but…

Pancreatic Tumors

CD40 Combination Therapy Can Shrink Pancreatic Tumors

A new combination of immunotherapy and chemotherapy for pancreatic cancer caused tumors to shrink in the majority of evaluable patients—20 out of 24 as of an interim analysis of the phase 1b trial data. The early findings provide hope that this strategy involving a CD40 antibody, a checkpoint inhibitor; also standard-of-care chemotherapy could be effective…

Metabolism

Reviewing Low-carb, Other Diets for Guidelines

With keto-friendly recipes sweeping social media, some followers of low-carb eating; are hoping for a nod of approval in the upcoming U.S. dietary guidelines; that advise Americans on what to eat. It may seem minor, but backers say low-carb’s inclusion; could influence nutrition advice; that doctors give and help shape government food programs; like school…

vaccine debate

Anti-vaxxers Appear to Be Losing Ground

As measles outbreaks spread across the U.S., our new look at how information; about vaccine safety and reliability spreads online suggests that the tide may be turning against the anti-vaccination movement. Between Jan. 1 and March 28, 387 people contracted measles in 15 U.S. states. Mumps is also coming back, with 151 infections in just…

Forensic

Forensic Anthropometric Legacy Of 19th Century Parma, Italy

A group of 19th century inmates dead in the prison of Parma are the protagonist of an incredible scientific collection. Lorenzo Tenchini started the creation of this collection and dedicated his work and his studies to its completeness. Anatomist and academic, Lorenzo Tenchini (1852–1906) dedicate his scientific studies to macroscopic anatomy; so particularly about central…

Occasional spoon feeding

Child's Eating Habits Is Actually Very Small

When it comes to avoiding picky eating and mealtime tantrums; parents are usually ready to try any method that promises their child will become a better and less fussy. This is in part why methods of giving solid food to infants have received a lot of attention in the last few years. Some think that…

Antibiotic

Emergency Physicians Refer Cellulitis Patients for Antibiotic Therapy

A program for referring adult cellulitis patients from the emergency department (ED) to outpatient parenteral antibiotic therapy (OPAT) clinics is associate with low failure rates and few adverse events, according to a prospective study.For physicians working in communities without OPAT services, I hope that this paper provides some encouragement that this is a safe and…

Transfusion medicine

Inherited Genetic Variation Linked To Risk Of T Cell Leukemia In Children

A study led by St. Jude Children’s Research Hospital has identified a novel risk variant associated with T cell acute lymphoblastic leukemia (T-ALL). The findings appear as an advance online publication in the Journal of the National Cancer Institute. “The inherited genetics underlying this rare type of leukemia were mostly unknown prior to our study,” said…

Cardiovascular Training Program

NIH Announces Funding Boost For Cardiovascular Training Program

The Detroit Cardiovascular Training Program at Wayne State University received notice that funding from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) will continue for the next five years with additional funding of $1.29 million. In addition, NIH has approved raising the trainee slots from four to six; so…

Stem cells

Endothelial Progenitor Cells Delay ALS Disease Progression

Transplantation of human bone marrow-derived endothelial progenitor cells (EPCs); into mice mimicking symptoms of amyotrophic lateral sclerosis; helped more motor neurons survive and slowed disease progression; by repairing damage to the blood-spinal cord barrier; University of South Florida researchers report. The new study, published in Scientific Reports, contributes to a growing body of work exploring…