All news from Marine Medicine

Marine-derived microorganisms

New Piperazine-Triones From A Marine-Derived Streptomycetes

Natural products have proved to a valuable source of new chemical entries in many therapeutic areas. Piperazine-triones are a rare class of natural products by fungi and actinomycetes. To date, only eleven polyketides bearing piperazine-triones motif have discovered in nature, including dithiodioxopiperazine; cytotoxic 12-dimethyl-12-oxodehydroechinulin and gliocladine C, lasiodiplines A. Actinomycetes characterized from the marine environment…

AIDS

First-ever Living Donor HIV-to-HIV Kidney Transplant

For the first time, a person living with HIV has donated a kidney to a transplant recipient also living with HIV. A multidisciplinary team from Johns Hopkins Medicine completed the living donor HIV-to-HIV kidney transplant. The doctors say both the donor and the recipient are doing well. This is the first time someone living with…

Nuclear medicine

Prognostic Role of Baseline 18F-FDG PET/CT Metabolic Parameters

Mantle cell lymphoma (MCL) is an aggressive lymphoma sub-type with poor prognosis and high 18F-FDG avidity at PET/CT; nowadays, no validated criteria for PET/CT in treatment response evaluation and prediction of outcome are present. The aim of study was to investigate whether the metabolic PET/CT features may predict treatment evaluation and prognosis in MCL. We…

Pharmacology

New Combination Therapy Found To Be Well Tolerated In Patients

A phase I clinical trial that set out to assess the safety of a new combination therapy for a type of aggressive brain tumor has found the treatment to be well tolerated in patients. Because The trial used a treatment combination of ADI-PEG20, pemetrex and cisplatin; which showed encouraging efficacy in patients with recurrent high-grade…

Immunity in mice

Nanovaccine Boosts Immunity in Mice

A new class of biomaterial developed by Cornell researchers for an infectious disease nanovaccine effectively boosted immunity in mice with metabolic disorders linked to gut bacteria – a population that shows resistance to traditional flu and polio vaccines. So, the study is the first to explore the interrelationship among nanomaterials, immune responses and the microbiome,…

Transfusion medicine

Step Towards Personalized Cancer Immunotherapy

Cells belonging to the body’s own immune system can help fight tumours. For several years now, this has allowed oncologists to use medications known as checkpoint inhibitors to encourage T cells to eliminate tumor cells. Last year the two scientists who discovered this therapeutic approach were awarded the Nobel Prize for Medicine. While doctors are…

Sports

The Keys to Perfect Lunges and Squats

The world of exercise has long been riddled with fitness myths, misconceptions, misperceptions and biased information. While much information is sound and well intentioned, some of it is designed to attract us to buy things, whether good for us or not. Collectively, sound information mixes with the “fluff” to make up a convoluted mass of confusion…

Radio therapy

MRI Provides Useful Findings In Discordant Core Biopsy

An essential part of breast intervention is the process of assessing concordance between imaging findings and core biopsy results. When pathology results are consider benign discordant; current standard of care is surgical excision, even though many of these lesions will ultimately be found benign. A new study published in the April 2019 issue of the…