Stem cells are the ultimate mother cells of the human body. Not only do they have the capacity to self-renew, they can develop into specific cell types as the body requires. But as the human body ages, the regenerative capacity of our stem cells diminishes. For example, as the capacity of hematopoietic stem cells (HSCs)…
Children’s Hospital Los Angeles has been awarded a $1.36M grant from The Leona M. and Harry B. Helmsley Charitable Trust to adapt a patient-driven model of care that Clinical Diabetes Director, Jennifer Raymond, MD, MCR, developed to increase treatment compliance among difficult to reach populations. Helmsley’s funding will also be used to investigate how to…
Oxylipins are oxygenated fatty acids derivatives distributed in a wide range of organisms; including plants and algae, where they are involves in the regulation of several physiological processes. In diatoms, these molecules are produced through an enzymatic cascade activated after cell breakage. In this process, specific lipoxygenases mediate the oxygenation of polyunsaturated fatty acids (PUFAs);…
An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine. Because The researchers believe the treatment could circumvent the need to use harsh; potentially life-threatening…
A study led by researchers at RCSI (Royal College of Surgeons in Ireland) has analyzed the pattern of skin cancer rates in kidney transplant patients; which suggests the increased risk is to the anti-rejection medications. The research is published in JAMA Dermatology and was a collaboration between the National Cancer Registry Ireland and the National…
A group of Hokkaido University scientists and collaborators have developed a method that could be used to treat heart failure patients whose exercise capacity has been impaired. The finding has expectation to help develop drugs that enable such patients to regain exercise capacity and improve their prognosis. The procedure was carried out on mice and…
Indian Space Research Organisation (Isro) has finally tasked the Indian Air Force for selection; training of 10 crew members for the country’s first human spaceflight programme or Gaganyaan. Talking to TOI, Isro chairman K Sivan said, “They have fixed all criteria and requirements for crew selection and training and submitted the same to the IAF.…
To evaluate the feasibility of quantifying visceral adipose tissue (VAT) on computed tomography (CT) and magnetic resonance imaging (MRI) scans, using freeware, as well as calculating intraobserver and interobserver reproducibility. We quantified VAT in patients who underwent abdominal CT and MRI at our institution between 2010 and 2015, with a maximum of three months between the two examinations.…
Transmucosal immediate-release fentanyl products are often use inappropriately, despite the existence of a risk evaluation and mitigation strategy (REMS) from the US Food and Drug Administration (FDA) for these products, new research suggests. Because In one of the first studies of its kind, investigators review FDA documents from 2012 to 2017 that are obtain through…
In the United States, motor vehicle accidents are a leading cause of injury and death; but with 29 Americans losing their lives to alcohol-related driving incidents daily; and alcohol consumption is the single greatest contributing factor to motor vehicle fatalities. A heated public debate has resulted surrounding the legal blood-alcohol-consumption (BAC) level; and new legislation…
In a study of older people with no clinical diagnosis or signs of dementia when hospitalized to repair hip fractures; Johns Hopkins researchers say they biomarkers of Alzheimer’s disease in most of the patients’ spinal fluid samples. The researchers say results of their study add to evidence that brain alterations that lead to poor balance…
Secondhand smoke is smoke from burning tobacco products, such as cigarettes, cigars, or pipes. Secondhand smoke also is smoke that has been exhaled, or breathed out, by the person smoking. Tobacco smoke contains more than 7,000 chemicals, including hundreds that are toxic and about 70 that can cause cancer. There is no risk-free level of…