Over the past two decades, several studies have demonstrated that GBM progression and recurrence is to epigenetic mechanisms including; mutations in IDH1/IDH2 genes, epigenetic modifying enzymes, histone deacetylases (HDACs); histone methyltransferases (HMTs); DNA methyltransferases (DNMT) and various DNA demethylases. Many novel inhibitors of these key epigenetic regulatory enzymes have been developed and tested in clinical…
Blocking two molecular pathways that send signals inside cancer cells could stave off esophageal adenocarcinoma (EAC), the most common esophageal malignancy in the United States, according to new research out of Case Western Reserve University School of Medicine. Researchers identified the pathways using advanced computational and genetic analyses of tumor biopsies from EAC patients. Specific…
Depleting the number of harmful B cells with novel immunotherapy that employs modified T cells may offer an effective strategy to treat lupus; according to a new study funded by the Lupus Research Alliance. These findings offer a renewed optimism for the elimination of B cells to provide a therapeutic option in lupus and pave…
An infant born with a relatively simple heart defect is far more likely to develop heart problems as an adult; researchers at the Stanford University School of Medicine have discovered. The risk is so great that someone born with a heart defect who has a heart-healthy lifestyle is twice as likely to develop heart problems…
Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease by long-term breathing problems and poor airflow. The main symptoms include shortness of breath and cough with sputum production. COPD is a progressive disease; meaning it typically worsens over time. Eventually everyday activities; such as walking. Chronic bronchitis and emphysema Chronic bronchitis and emphysema are older terms used for…
A recent review of published data indicates that protein ingested prior to overnight sleep stimulates protein synthesis. A bedtime protein shake could, therefore, help build muscles mass after resistance exercise and prevent muscle wastage in the elderly. The synergistic effect between nutrition and exercise on the synthesis of muscle protein has well establishment. Resistance exercise…
In the world of superbugs (bacteria that has grown resistant to antibiotics) Clostridioides difficile; a bacterium that causes diarrhea and colitis; is among the most stubborn. In 2013 the Centers for Disease Control called C. diff an “urgent threat” after causing 30,000 deaths in 2011. So it is often picked up by patients over 65 who…
University of Saskatchewan PhD student Yi Wang developed software that can get higher image quality. It improves current computer-aided diagnosis (CADx) technology, which assists doctors to detect diseases from medical imaging scans such as ultrasound, computer tomography (CT) and retinal fundus imaging, which captures photos of the back of the eye. Wang’s software makes diagnosis…
Obsessive–compulsive disorder (OCD) is a mental disorder in which a person feels the need to perform certain routines repeatedly (called “compulsions”), or has certain thoughts repeatedly (called “obsessions”). The person is unable to control either the thoughts or activities for more than a short period of time. Common compulsions include hand washing, counting of things, and checking to see if a door…
A new study, recently published in Nature Communications, at infections in Danish youth with CF over a period of 10 years. This is the largest longitudinal study to date of the evolution; both involving traits and genes of the disease-causing microbes that persistently infect young CF-patients. CF-patients have a genetic defect which results in dehydrated sticky…
Frailty, a decline in function and resistance to short-term stress that typically occurs in old age; is linked to more complications after an operation among adults of all ages; according to researchers of a large new study published as an “article in press”; on the Journal of the American College of Surgeonswebsite in advance of…
The recent measles outbreaks across the country emphasize the importance of vaccinations. “For many infectious diseases, we rely on herd immunity to prevent outbreaks of vaccine-preventable infections. Herd immunity is the protection of the ‘herd,’ our population; by preventing infections in the vast majority people;” said Kate Langwig, an infectious disease ecologist at Virginia Tech.…