A new study indicates that both high-grade abnormal cellular changes (dysplasia) and esophageal adenocarcinoma (a form of cancer) have increased in the last 25 years among people with a digestive condition known as Barrett’s esophagus. The study report, Increasing prevalence of high-grade dysplasia and adenocarcinoma on index endoscopy in Barrett’s esophagus; over the past 2…
A novel, synthetic DNA vaccine developed at The Wistar Institute induces protective immunity against Mayaro virus (MAYV), a mosquito-borne infection endemic to South America, that has the potential to become a global emerging viral threat. Study results were published in PLOS Neglected Tropical Diseases. However, since its discovery in 1954, MAYV infections have been confined to the…
For the first time, researchers have revealed the different molecular identities of important immune cells, called T regulatory cells, using single cell genomics, in both mouse and human peripheral non-lymphoid tissues such as skin and colon. The researchers from the Well come Sanger Institute and their collaborators revealed that T regulatory cells have tissue-specific receptors…
Zika virus (ZIKV) has association with birth defects and pregnancy loss after maternal infection. Because dengue virus (DENV) and ZIKV co-circulate, understanding the role of antibody-dependent enhancement in the context of pregnancy is critical. Here, we showed that the presence of DENV-specific antibodies in ZIKV-infected pregnant mice significantly increased placental damage, fetal growth restriction, and…
In the current issue of Cardiovascular Innovations and Applications (Special Issue on Stable Ischemic Heart Disease, Volume 3, Number 3, 2019, pp. 285-290(6); DOI: https://doi.org/10.15212/CVIA.2017.0073 Cody Schwartz and David Winchester from the Malcom Randall VAMC, Gainesville, FL, USA consider diabetes mellitus and stable ischemic heart disease. More than 30 million Americans have diabetes mellitus (DM), and heart…
One in three hospitalized patients eat a quarter of their meals or less, putting them at risk for malnutrition and jeopardizing their recovery, a new study shows. Patients who eat none of their food despite allowing to eat; but had a sixfold higher risk for in-hospital death compared with those who ate some of their…
Pharmacogenomics combines pharmacology, the science of drug actions, with genomics, the study of genes, to predict an individual’s response to specific drugs. The goal of pharmacogenetics is to enable physicians to choose effective, safe medications and doses tailored to a person’s genetic makeup. “The integration of these two fields has the potential to save lives…
An Australian initiative is successfully helping emergency doctors and nurses develop better treatments, diagnostics and services for improving patient care. After seeing first-hand the problems time-poor emergency clinicians had in taking part in research projects the Emergency Medicine Foundation – Australia (EMF) launched a Research Support Network (RSN) in late 2015. EMF piloted the program…