All news from Epidemiology

Non-polio Enterovirus: Outbreak Of Paralyzing Disease

The Translational Genomics Research Institute, an affiliate of City of Hope, has identified a polio-like virus as a potential cause of an outbreak of a disease known as Acute Flaccid Myelitis, a crippling condition that causes muscle weakness and paralysis usually among children. At the request of Arizona and Maricopa County health officials, TGen was tasked with trying to identify the microbial cause of the outbreak of AFM among as many as 11 patients at a Phoenix-area hospital.

Hesitant To Vaccination? A Major Global Health Threat

Vaccine hesitancy is among the top 10 health threats facing the world in 2019, the World Health Organization says. The movement against vaccinations has taken hold in a number of countries, including the United States. The percentage of American children ages 19 to 35 months who have not been vaccinated has quadrupled since 2001, according to U.S. Centers for Disease Control and Prevention data, Newsweek reported. 

Parasitic Diseases? CRISPR-Cas9 Shown To Limit Impact Of Them

For the first time, researchers have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and for liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer. Their findings are found in two papers published today in the journal eLife.

Cancer Insight: Knockout Study Of Mouse MicroRNA Shows

Researchers used knockout mouse models created by gene editing to reveal that the miRNA miR-146b, like miR-146a, is involved in the development of cancers, with them having similar but not identical effects. The knockout mice should help in the fight against cancers involving miRNA dysregulation. A team at Tokyo Medical and Dental University(TMDU) has revealed the molecule to cancer development, showing that the absence of the lead to dysregulation of the cell cycle, albeit with differing cancer-related outcomes.

Revolution In Medicine: New 3D Nanoprinting Strategy

Engineers at the University of Maryland (UMD) have created the first 3D-printed fluid circuit element so tiny that 10 could rest on the width of a human hair. The diode ensures fluids move in only a single direction, a critical feature for products like implantable devices that release therapies directly into the body. The microfluidic diode also represents the first use of a 3D nanoprinting strategy that breaks through previous cost and complexity barriers hindering advancements in areas from personalized medicine to drug delivery.