All news from Health & Hospital Administration

Price Hikes On Older, Brand-Name Drugs Share Blame For Surging Drug Costs

The pharmaceutical industry, in recent years, has been marked by a cycle of outrage from patient groups, insurers and politicians each time a particularly expensive new drug hits the market. The considerable ticket price attached to blockbuster newcomers inevitably draws a widespread public outcry, and, lingering in the media spotlight, are often cited as the most likely culprits driving the skyrocketing drug costs in the United States.

In Creation Of Clinical-grade Bone: Scientists Make Progression

A team of scientists from the New York Stem Cell Foundation Research Institute reported in Stem Cell Research and Therapy that they have made valuable progress toward creating clinical-grade cells for treatment of bone disease and injury. In their study, the team identified two types of growth media that could support effective expansion of mesenchymal progenitor cells from stem cells in a clinically compatible, Good Manufacturing Practice setting. GMP guidelines require that cells to be used as therapies are created without the use of animal-derived substances.

Less Ketone Body Utilization: Blood Flows Slowly To Heart

Ketone bodies (acetoacetic acid, beta-hydroxybutyric acid) are metabolites that can be used as energy sources like glucose and fatty acids. They can be converted into acetyl-CoA, which produces energy via the Krebs cycle in the mitochondria, and are typically used as an alternative energy source during starvation, fasting, or periods of high-intensity exercise.

However, their utilization rate in the heart and effect on disease conditions was poorly understood. Researchers have measured the ketone body utilization rate in the heart and confirmed that it decreases when the heart is in a state of reduced blood flow (myocardial ischemia).