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New Device to Study The Role of Cadherin in Cellular Dyanmics

As cells divide to form tissues and organs in multicell organisms, they move to where they belong, informed by a series of cues that scientists have yet to observe or fully understand. Exactly how these local in-plane shear forces are spread throughout a tissue — important in collective tissue behavior — is not understood, in part because it is difficult to apply direct, localized shear within a tissue.

In a paper published in the journal eLife, Pruitt and her co-author describe a new device that allows them to introduce perturbations into the system, observe cellular response behavior and measure overall force, providing new insights into the role of cadherin in cellular dynamics.