Researchers have discovered how a gene involved in regulating hormone receptors may contribute to drug resistance in some prostate cancer patients. Their findings, published in eLife, suggest that disrupting specific activity of the GREB1 gene could be explored for developing more effective therapies in future.
Quitting smoking is one of the hardest things to do, but studies have found that one strategy in particular can help many people: Start anti-smoking medication well before your intended quit date. Under traditional prescribing guidelines, people who plan to quit smoking with the help of a medication begin taking their anti-smoking drug about one week before their set quit date. But about 75 percent of people who try to quit go back to smoking within a year.
So what's the solution? Research done at the University at Buffalo, in New York, showed that simply starting the drugs four weeks in advance can increase the success rate. One study was done on bupropion, known by the brand name Zyban, and similar research has involved both nicotine replacement therapy and varenicline (Chantix).
The replication of a bacterial virus is not necessary to cause lethal disease in a mouse model of a food-borne pathogen called Enterohemorrhagic Escherichia coli (EHEC), according to a study published January 10 in the open-access journal PLOS Pathogens by Sowmya Balasubramanian of Tufts University School of Medicine, and colleagues. The surprising findings could lead to the development of novel strategies for the treatment of EHEC and life-threatening kidney-related complications in children.
Responding to an outbreak of chicken pox in the Rohingya refugee camps, health sector partners led by the Ministry of Health and World Health Organization have stepped up surveillance and initiated measures to curtail further spread of the disease and prevent any complications.
Brazilian researchers are the first to demonstrate the action of PRIMA-1 against amyloid aggregates of mutant p53 protein, structure found in more than half of malignant tumors. The novel study is the first to demonstrate the action of PRIMA-1 on the inhibition of aggregates of the mutant p53 protein. The results are published in the Journal of Biological Chemistry.
A number of people trying to maintain good health and also exploring to buy a health insurance policy to cover their health risks find existing health insurance policies in the country confusing and expensive. Moreover, an even larger chunk of people do not trust the healthcare ecosystem.
These are the findings of a study, GOQii India Fit Report 2019, by preventive healthcare and fitness platform GOQii. The findings are based on responses from 700,000 users of the company’s fitness app.
A team at LSTM with their collaborators in Malawi and Denmark have provided, for the first time, evidence which links the ability of red blood cells infected with the malaria parasite to bind to the cells lining the blood vessels of the brain, with the clinical syndrome cerebral malaria. The study was published in the journal EMBO Molecular Medicine.
An international team of researchers have carried out a review of the evidence examining what influences people who are HIV positive to go to health services and then stay on antiretroviral drugs in Africa. In a paper published in the Journal PLOS One the team, led by LSTM's Professor Paul Garner, used advanced methods of thematic synthesis to examine over 59 studies carried out in Africa, extracting key messages from the qualitative research.
A set of fortunate circumstances may have prevented the UK from being harder hit by bluetongue in the past but the threat of future outbreaks is only set to increase, new research reveals. Scientists at the University of Liverpool have used mathematical modelling to identify why the 2007 UK outbreak of bluetongue — a viral disease spread by midge bites that affects sheep and cattle — was smaller than it could have been and to predict the future impact of the disease in northern Europe as the climate warms.
A new study of around 8,000 middle-aged and older adults found that swapping a half-hour of sitting around with physical activity of any intensity or duration cut the risk of early death by as much as 35%. The findings highlight the importance of movement — regardless of its intensity or amount of time spent moving — for better health. The study was published online in the American Journal of Epidemiology.
Developed over decades, pulmonary oscillometry has re-emerged as a noninvasive and effort-independent method for evaluating respiratory-system impedance in patients with obstructive lung disease.
Herpes viral infections use the ancient genetic material found in the human genome to proliferate, mimicking the same process tumors have been found to manipulate, Mount Sinai researchers have shown for the first time. These observations provide further insight about how herpes viruses can manipulate the immune system in ways that may drive neurodegenerative diseases like Alzheimer's, according to the study, published in Nature Communications.