A recently discovered protein, alpha-synuclein, has become one of the most attractive targets for developing new drugs with the potential to slow down or arrest the progression of Parkinson's disease (PD). Experts in the field of Parkinson's research have now proposed a roadmap for preclinical and clinical trials investigating compounds targeting alpha-synuclein. Their consensus white paper is published in the Journal of Parkinson's Disease .
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A research team led by scientists at the Columbia University Mailman School of Public Health report on a new method to help health officials control outbreaks of methicillin-resistant Staphylococcus aureus, or MRSA, a life-threatening antibiotic-resistant infection often seen in hospitals. The researchers are the first to reveal the invisible dynamics of the spread of these outbreaks and demonstrate a new, more effective method to prevent their spread. Findings are published in the eLife journal .
Contraindicated statin use declined between 2007 and 2015 in HIV-infected adults treated with antiretroviral therapy (ART), while overall use remains suboptimal, researchers report.
Scientists made hollow nanosized boxes with corner holes, demonstrating how these ''nanowrappers'' can carry and release DNA-coated nanoparticles. Using a one-step chemical synthesis method, they engineered hollow metallic nanosized boxes with cube-shaped pores at the corners and demonstrated how these "nanowrappers" can be used to carry and release DNA-coated nanoparticles in a controlled way. The research is reported in a paper published in ACS Central Science.
A jagged little protein appears to be key to how to stem cancer cells differentiate and enable metastasis, according to researchers at Rice University and the Duke University School of Medicine.
SpaceLife Origin, a new start-up based in Netherland, is looking to send a pregnant woman to space where she will give birth to her child. Dubbed as Mission Cradle , this daring endeavor to have a pregnant woman deliver her child at 250 miles above Earth under the care of a "trained" and "world-class medical team."
Researchers have identified a group of genes that induces differences in the developing brains of male and female roundworms and trigger the initiation of puberty, a genetic pathway that may have the same function in controlling the timing of sexual maturation in humans.
For infants younger than 3 months undergoing venipuncture, eutectic mixture of lidocaine (EMLA) cream has only minimal pain relieving effects relative to placebo and no benefit over sucrose and / or breastfeeding, according to a meta-analysis of published studies.