A new study conducted on human cells and mice, published in Gastroenterology, has shown that the anti-inflammatory action of a biological clock protein could prevent the onset of fulminant hepatitis, by alleviating symptoms and increasing survival rates.
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A study by researchers at the University of Arizona Cancer Center and Cancer Research UK has shown that triple-negative breast cancer that is deficient in the retinoblastoma (RB) tumor suppressor is susceptible to drugs that target certain proteins key to cell division and DNA replication. The findings were published in the journal Cell Reports.
Weaning failure is a crucial hindrance in critically ill patients. Rapid shallow breathing index (RSBI), a well-known weaning index, has some limitations in predicting weaning outcomes. A new weaning index using point-of-care ultrasound with diaphragmic thickening fraction (DTF) has potential benefits for improving weaning success. The study researchers aim to evaluate the efficacy of a combination of DTF and RSBI for predicting successful weaning compared to RSBI alone.
A new discovery sheds new light on the pathology of Alzheimer's disease (AD) as well as on the communication between the brain and the rest of the body. An association between inflammation biomarkers in both blood plasma and cerebrospinal fluid (CSF) and markers of AD-associated pathology. The findings were published today in the Journal of Alzheimer's Disease.
Twenty-five years ago, an unusual inherited form of high blood pressure was first described in an Australian family. Its genetic cause, however, had remained elusive. Using modern sequencing methods, an international research team led by BIH Johanna Quandt Professor Ute Scholl has succeeded in detecting mutations in a new disease gene (CLCN2), present in this family and seven others that are responsible for the development of a familial form of hyperaldosteronism .
The systematic review was conducted with the first objective aimed at providing an overview of the physiological characteristics commonly evaluated in rugby and the corresponding tests used to measure each construct. Secondly, the measurement properties of all identified tests per physiological construct were evaluated with the ultimate purpose of identifying tests with the strongest level of evidence per construct.
According to this study, researchers showed the rates of the deadly skin cancer known as melanoma have dropped among Americans aged 15 to 44, a new report from the U.S. Centers for Disease Control and Prevention. The study was published online in the journal JAMA Dermatology.
The government has not disclosed the names of the brands that have high levels of lead in their powdered milk products. Parents and consumer rights campaigners have expressed concern about the government’s silence. Earlier, hazardous levels of lead were discovered in the powdered milk products of five companies.
A study analyzing the features of "triple-negative" breast cancer has found that the loss of a specific tumor suppressor provides clues about potential new treatment approaches .
Researchers from Tokyo have identified a key process, in which Ebola virus incorporates a cellular enzyme into its virus particles, facilitating the infection to the target cells. The discovery provides a novel target for developing antiviral drugs. The study was published in the journal PLOS Pathogens.
According to a European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP) voted to recommend granting marketing authorization for recombinant, adjuvanted herpes zoster vaccine (Shingrix, GlaxoSmithKline [GSK] Biologicals, SA] to prevent shingles and postherpetic neuralgia in patients aged 50 years and older. The findings published in the European public assessment report.
In this new study, scientists identified the beneficial effects of a CnAβ1-induced metabolic pathway in the hypertrophic heart, and may open the path to new treatment strategies. The findings also show how alternative forms of the same protein, produced from the same gene, can have opposite effects on a biological or pathological process. This study has published in the Journal of the American College of Cardiology (JACC).