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Occurrence of Oropharyngeal HPV And Crypt Biofilm In Tonsil Tissue

Researchers determined the prevalence of oropharyngeal HPV and to determine the spatial relationship between the virus and crypt biofilm in tonsil tissue. The presence of latent HPV infection in tonsil tissue of healthy adults may provide an explanation for a component of this process and contribute to the understanding of HPV-associated squamous cell carcinoma oncogenesis of the oropharynx.

Renal Cell Cancer: Support for Upfront Immunotherapy

In a phase 3 study of patients with previously untreated metastatic renal cell cancer (mRCC), use of the anti-PD-L1 immune checkpoint inhibitor atezolizumab (Tecentriq, Roche) in combination with bevacizumab (Avastin, Roche) delayed disease progression by about 3 months longer than standard treatment with sunitinib (Sutent, Pfizer), with fewer side effects.

Attitudes of Clinicians about Practice Variation

According to a study published in the PLoS One, the physicians, nurse practitioners, and physician assistants responding to the survey agreed that practice variation should be reduced, but many seemed to have reservations about the feasibility of this aim. Time to appraise and apply practice standards was rated as most helpful in standardizing practice.