All news from Anaesthesiology

Human Intestinal Cell Lining Created An Individual's Living Tissue

Researchers have established how cells of a human intestinal lining created outside an individual's body mirror living tissue when placed inside microengineered Intestine-Chips, opening the door to personalized testing of drug treatments.

The findings have the potential to change how patients are treated for debilitating, inflammatory gastrointestinal diseases with a genetic component, such as Crohn's disease, ulcerative colitis and irritable bowel syndrome. This study have been published in Cellular and Molecular Gastroenterology and Hepatology.

Benefits And Harms of CES For Adult Patients

In this study, researchers evaluated the benefits and harms of CES for adult patients with chronic painful conditions, depression, anxiety, and insomnia. Several databases from inception to 10 October 2017 without language restrictions and references from experts, prior reviews, and manufacturers. Randomized controlled trials of CES versus usual care or sham CES that reported pain, depression, anxiety, or sleep outcomes in any language.

Worrying Levels of Microplastics Found in Northwest Atlantic Fish

A new study, published the journal Frontiers in Marine Science, sheds light on the magnitude of microplastic pollution in our oceans. The study found microplastics in the stomachs of nearly three out of every four mesopelagic fish caught in the Northwest Atlantic — one of the highest levels globally.

These findings are worrying, as the affected fish could spread microplastics throughout the ocean. The fish are also prey for fish eaten by humans, meaning that microplastics could indirectly contaminate our food supply through the transfer of associated microplastic toxins.

Transcription Factor Opens Genome for T cell Development

In the new study published in Immunity, researchers from the Perelman School of Medicine at the University of Pennsylvania, describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in developing new therapies using epigenetic drugs to alter T-cell fate in cancer, autoimmune disorders, and infectious diseases.

Influenza, Tdap Vaccination in Pregnancy: Benefits to Infants

Maternal influenza and tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) vaccinations during pregnancy do not increase the risk for hospitalization or death among infants from birth to 6 months, a new study showed. The data add to a growing body of evidence on the safety of vaccination during pregnancy. The study findings are published in the journal Pediatrics.

[18F]-FPEB: Binding Potential increased in Individuals with Autism

The present study represents the first time that positron emission tomography (PET) imaging has been used to determine mGluR5 binding in vivo in brains of adults with autism and controls, using [18F]-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ([18F]-FPEB), a potent, selective, and systemically active antagonist of mGluR5.

Researchers aimed to investigate if mGluR5 expression in vivo replicated the results obtained by postmortem experiments and whether these changes (if any) positively correlated with autism symptom severity.