All news from Anaesthesiology

Risks of Transplants Minimized

A bone marrow transplant is often the only therapy available to save leukemia patients, but the risk of complications is high. In spite of devoting considerable time and effort to finding a suitable donor, nearly half of all patients experience an unwanted reaction of their immune system, which often attacks their skin and liver and in up to 50% of cases the intestines.

Researchers at FAU have succeeded in deciphering what causes this in some instances life-threatening inflammation of the intestines, possibly opening up new approaches for treatment. They have published the results of their research in the Journal of Clinical Investigation.

An Achilles heel of Trypanosomes discovered

Trypanosomes are single-celled parasites that cause diseases such as human African sleeping sickness and Nagana in animals. But they are also used in basic research as a model system to study fundamental biological questions.

Researchers of the University of Bern have now investigated how trypanosomes equally distribute their "power plant" to the daughter cells during cell division. The discovered mechanism potentially opens new avenues for drug interventions.

Typbar-TCV: First African Child Immunized

The first African child was vaccinated with the newly prequalified World Health Organization (WHO) typhoid conjugate vaccine (TCV), Typbar-TCV, in Malawi. The clinical trial is led by Principal Investigator Professor Melita Gordon of the University of Liverpool and the Malawi-Liverpool-Wellcome Trust (MLW) Clinical Research Programme. A total of 24,000 children in Ndirande and Zingwangwa townships will be enrolled in the Malawi trial.

Pyoderma Gangrenosum Showed Clinical Presentation Among Different Age Groups

A study showed of 356 cases of PG showed that although clinical presentation is similar among different age groups, patients with pyoderma gangrenosum who are younger than 65 years are more likely to have associated inflammatory bowel disease, while those 65 years or older are more likely to have associated inflammatory arthritides, solid organ and hematologic malignant neoplasms, and hematologic disorders; specifically, monoclonal gammopathy of undetermined significance, myelodysplastic syndrome.

Cellulitis Was a Cost-Effective Intervention To Prevent Misdiagnoses

According to this study, researchers examined cellulitis a bacterial infection of the skin is a common medical condition, yet there is no diagnostic tool for it currently available. The only way to diagnose cellulitis is based on the appearance of the affected area and the patient's reported symptoms. Many other medical conditions cause skin inflammation that mimics the appearance of cellulitis and are commonly misdiagnosed. This study is published in JAMA Dermatology.

Cancer Pioneer Employs Physics to Approach Cancer

In the cover article of Oncotarget, James Frost, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer. Co-author Dr. Coffey, ex-deputy director of the Johns Hopkins Kimmel Cancer Center and Professor of Urology, died before this paper was published at 85.

To Examine the Healing Effect Of 1?-Hydroxyvitamin D3 on BPPV

In this study, researchers investigated the healing effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). This is a kind of clinically common peripheral vestibular disease, which has the highest incidence rate in vertigo derived from the inner ear. Its main manifestation is that the transient paroxysmal vertigo can be caused when the head moves to a specific position, accompanied by nystagmus and autonomic neural symptoms.