All news from Anaesthesiology

MCF-7 Breast Tumor Targeting and Imaging

In the present study, researchers radiolabeled FROP-1 peptide through practicing HYNIC as a chelating moiety (at the C-terminus) and Lys residue as a spacer in order to develop a 99mTc-HYNIC-(tricine-EDDA)-Lys-FROP for the targeting of the MCF-7 breast cancer cells.

Effect of Different Compositions of OD-ECM by Different Stages of Osteogenesis

The aim of the present study was to investigate the effect of different compositions of OD-ECM by different stages of osteogenesis. The researchers investigated the re-seeded osteoblast effect on different compositions of ECM as followed: GM-ECM, OD-ECM-2 W, and OD-ECM-4 W. Differentiation and maturation of re-seeded osteoblasts were determined by analysis of the known indicators of the osteoblast phenotype, calcification, mineralization, and protein activity under a growth medium and osteogenic differentiation medium.

Soccer Benefits to Health

According to a research review, compared to inactive people, recreational soccer players have lower cholesterol, blood pressure and resting heart rates as well as less fat mass.

Glaucoma: New Directions in its Understanding and Prevention

Two distinctive handfuls of short molecules that regulate gene expression have been found in the eye fluid of patients with two distinct types of vision degenerating glaucoma.

These differentially expressed microRNAs point the way toward finding more genes associated with glaucoma, more clues about how these glaucoma types each go about damaging our optic nerve and potential new points of intervention, the scientists say.

Leukaemia: Transcription Factor STAT5 was Targeted for Cure

Acute myeloid leukaemia is the most common type of acute cancer of the blood and bone marrow in adults. AML progresses quickly and only 26% of the patients survive longer than five years as resistance against established treatments develops.

The most common molecular cause is FLT3 mutations, which result in hyper-activation of STAT5. A research consortium now reports on an early preclinical effort targeting STAT5 that integrates well with existing therapies.

IL-4 Receptor Protein Active in Anaphylaxis is a Promising Target for Therapy

Prospects for inhibiting the most dangerous symptoms of allergic reactions may be brighter with the publication of a new study that identifies a possible target for drug therapies.The study published in the Journal of Allergy and Clinical Immunology found that several proteins can interact in blood vessels to intensify the respiratory and circulatory symptoms of a severe allergic reaction known as anaphylaxis.