All news from Lab Medicine

CRISPR-Based Treatment For Acute Myeloid Leukemia

Researchers from Cold Spring Harbor Laboratory have developed a method based on CRISPR gene editing tools to screen large numbers of genes, seeking to discover their impact on cancer cell survival. The team has now deployed a technology against leukemia. 

Marine Algae: A New Antileishmaniasis Drug

Leishmaniasis is a vector-borne disease caused by protozoan parasites. The current review describes compounds from marine macroalgae along with their antileishmanial activity and provides prospective insights for antileishmanial drug discovery.

Combined Disinfection Treatment for Safer Drinking Water

In spite of good progress in water hygiene during the recent decades, contaminated water still causes millions of diseases every year. Most of these diseases are caused by enteric viruses, and better water disinfection methods could help prevent discomfort and even save lives.

A new study shows that a combined disinfection treatment with chlorine and UV radiation can be highly effective in water disinfection. The findings were originally reported in Journal of Water and Health, and Water.

TDF: Ineffective in Mother-to-Child Transmission of Hepatitis B Virus

Tenofovir disoproxil fumarate (TDF), an antiviral drug commonly prescribed to treat hepatitis B infection, does not significantly reduce mother-to-child transmission of hepatitis B virus when taken during pregnancy and after delivery, according to a phase III clinical trial in Thailand funded by the National Institutes of Health.

The study tested TDF therapy in addition to the standard preventative regimen—administration of hepatitis B vaccine and protective antibodies at birth—to explore the drug's potential effects on mother-to-child transmission rates. The results appear in the New England Journal of Medicine.

Cardiac PET More Effective Than SPECT scans

Patients who receive cardiac positron emission testing (PET) imaging instead of single photon emission computed tomography (SPECT) scan experienced a significant increase in the detection of severe obstructive coronary artery disease.

Antibiotic-Resistant Bacteria Cases Have Increased In Hospital

In the study, Cases of antibiotic-resistant bacteria in hospitals have increased dramatically in recent years, and the health system faces tremendous problems as a result. Alongside Staphylococcus aureus (MRSA) and Klebsiella pneumonia, another pathogen has now arrived on the scene, Acinetobacter baumannii. Acinetobacter baumannii infections are often fatal due to its increasing antibiotic resistance. The study was published in the journal mBio.

Nepalese with Earthquake-Related Spinal Cord Injury and Psychosocial factors

Nepal is a developing country which has a different culture, geographical distribution, and healthcare system. Nepal is a collectivist society and many Nepalese live in rural areas that lack the availability of healthcare services. Thus, factors affecting resilience among Nepalese with earthquake-related SCI could be different from people in other geographical and cultural contexts.

The present study hypothesized that psychosocial factors, i.e., social support, self-efficacy, spirituality, and depressive mood, determine resilience among Nepalese with the 2015 earthquake-related SCI.

MicroRNA as a Biomarker in Bronchopulmonary Dysplasia in Premature Infants

Researchers report discovery of a strong predictive biomarker for bronchopulmonary dysplasia, and they show a role for the biomarker in the pathogenesis of this neonatal lung disease. These results open the path to possible future therapies to prevent or lessen BPD, which is marked by inflammation and impaired lung development, and mortality or morbidity.

Non-alcoholic Fatty Acid Liver Could Be Improved By Gastrointestinal Hormone

Through a randomized, double-blind, placebo-controlled phase II clinical trial, at the University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).