Allogeneic Hematopoietic Cell Transplantation (HCT) is a curative and established treatment approach for patients with hematological malignancies such as leukemia. However, graft-versus-host disease (GvHD), where the transplanted stem cells react against the tissues of the patient, is a major complication and often results in late morbidity and mortality, as well as in a reduction of quality of life. The accurate evaluation of this disease is thus of paramount importance to correctly evaluate and optimize transplantation outcome.
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A major UK survey has shown that patients with urological cancer such as prostate, bladder or kidney cancer are five times more likely to commit suicide than people without cancer.
The analysis also shows that cancer patients generally are around three times more likely to commit suicide than the general population and that the proportion of attempted suicides which result in a completed or successful suicide was higher in cancer patients, with a higher proportion still in patients with urological cancers.
Researchers at the University of Sheffield have successfully used computer simulated models and medical imaging to test the strength of young children's bones, producing results which could help car seat manufacturers design safer car seats for young children.
In this work, researchers quantified the variation of significant retinal blood vessel (BV) position outside optic nerve head (ONH) among glaucoma patients. More specifically, they investigated quantitative relationships between BV position and glaucoma diagnostic parameters
Recurrent acute otitis media (rAOM, recurrent ear infection) is a common childhood disease caused by bacteria termed otopathogens, for which current treatments have limited effectiveness. Generic probiotic therapies have shown promise, but seem to lack specificity. They hypothesized that healthy children with no history of AOM carry protective commensal bacteria that could be translated into a specific probiotic therapy to break the cycle of re-infection.
Neonatal nephron loss may follow hypoxic-ischemic events or nephrotoxic medications. Its long-term effects on the kidney are still unclear. Unlike term infants, preterm neonates less than 36 weeks gestational age show ongoing nephrogenesis. We hypothesized that nephron loss during nephrogenesis leads to more severe renal sequelae than nephron loss shortly after the completion of nephrogenesis.
In this study, approximately 80% of patients presenting to emergency departments (ED) with chest pain do not have any true cardiopulmonary emergency such as acute coronary syndrome (ACS). However, psychological contributors such as anxiety are thought to be present in up to 58%, but often remain undiagnosed leading to chronic chest pain and ED recidivism.
Stable posture and body movement in humans are dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement.
Three new polyoxygenated steroids, michosterols A– C, and four known compounds were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. It exhibited potent anti-inflammatory activity.
Vascular endothelial growth factor-C, a lymphangiogenic growth factor results in cell proliferation and survival. The interruption of VEGF-C signaling might be a potential therapeutic target for antileukemic treatment in AML patients.
In an observational study of patients who received ledipasvir and sofosbuvir treatment for HCV, it was found that contrary to guidelines, 8 and 12-week treatment regimens did not result in statistically significant differences in SVR12 in black patients.
In this study, researchers assessed that the Congo nation is suffering from a cholera outbreak that has swept through villages ravaged by conflict and is now spreading quickly in the overcrowded capital, officials and health workers. Cholera outbreaks occur regularly in the vast Central African country, but this is the worst in more than 20 years.