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Unstructured Proteins: Ultra-High-Affinity Interactions Seen

Researchers have discovered a previously unknown way in which proteins interact with one another and cells organize themselves. This new mechanism involves two fully unstructured proteins forming an ultra-high-affinity complex due to their opposite net charge. Proteins usually bind one another as a result of perfectly matching shapes in their three-dimensional structures.

Effectiveness of HIV testing in Emergency Departments

South Africa has the worst epidemic of HIV in the world. According to the Joint United Nations Programme on HIV/AIDS, 19% of the global number of people living with HIV are in South Africa. Many people in South Africa and around the globe do not even know they have HIV.