All news from Anaesthesiology

To Compare Hematoma Block And Procedural Sedation And Analgesia

The study is to differentiate Procedure sedation and analgesia (PSA) and Hematoma block(HB) for adult and pediatric patients during reduction of displaced distal radius fracture to identify the level of pain relief, the frequency of adverse effects (AEs), and reduction failure. Procedure sedation and analgesia (PSA) is often used to alleviate discomfort and to facilitate fracture reduction for patients with distal radius fracture in emergency departments and clinics, but risks of respiratory distress and needs for different levels of monitoring under PSA.

Security Chief Detected For Immune System

St. Jude Children's Research Hospital scientists have identified a key molecule that serves as a "security chief" to help the immune system quickly recognize and fight infections with dangerous gram-negative bacteria like Salmonella.

Osteoclasts Form a Specialized Cell-Matrix Adhesion Structure

A study emphasizes the sealing zone is a dynamic actin-rich structure that defines the resorption area of the bone. The detailed dynamics and fine structure of the sealing zone have been elusive. Osteoclasts plated on glass do not form a sealing zone but generate a separate supra-molecular structure called the “podosome belt".

Molecular Structure Of ‘Anti-Aging’ Protein

Researcher reveals the molecular structure of the so-called "anti-aging" protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. The study was published in Nature. They demonstrated that mice lacking either a-Klotho or the hormone FGF23 suffered from premature and multiple organ failures as well as other conditions, including early onset cardiovascular disease, cancer, and cognitive decline.