A genetically engineered ferret could help reveal how humans got their big brains. By inactivating a gene linked to abnormally small brain size in humans, researchers have created the first ferret with a neurological mutation. Although the original impetus of the work was to study human brain disease and development, says Howard Hughes Medical Institute (HHMI) Investigator Christopher Walsh, the results also shed light on how the human brain expanded during evolution. The study was published in the journal Nature.
All news from Anaesthesiology
Researchers could develop new cancer drugs that specifically target Gαs. A new view of a protein frequently mutated in pituitary tumors is overturning conventional wisdom and could point to novel targets for cancer drugs. The protein, a "G protein" called Gαs, initiates messages inside cells. But a single mutation surprisingly alters Gαs action. The protein's molecular "off switch" actually switches activity on. The study was published in the journal Cell.
Scientists examine the near-atomic detail the smallest protein ever seen by the technique, called cryo-electron microscopy, enables scientists to see large biomolecules, such as viruses, in extraordinary detail. The study was published in the journal Proceedings of the National Academy of Sciences.
A study focused on the anchoring of ion channels and micropeptides in heart muscle cells, by understanding and research on the molecular mechanisms underlying neurological and heart diseases. Researchers team are attempting to understand how the sense of touch works and how neurons perceive mechanical stimuli. It is already known that when skin is touched, an electric signal is generated in the ion channels of the neuronal membrane.
According to a study, the researcher examines that a key factor in reducing the risk of diabetic ketoacidosis(DKA), a potentially life-threatening complication of type 1 diabetes, in children at diagnosis of type 1 diabetes, is having a regular health care provider. Type 1 diabetes mellitus is a common chronic childhood disease. If untreated, it can result in DKA, the most common cause of death in children with type 1 diabetes.
DKA occurs as the body breaks downs muscle and fats for energy in place of sugar, releasing fatty acids (ketones) into the blood. The study was published in CMAJ(Canadian Medical Association Journal). "Having a regular primary care provider was associated with a reduced risk of DKA at diabetes onset, but this protection reached statistical significance only among those 12-17 years of age," writes Dr. Meranda Nakhla.
Scientists from the Gates Center for Regenerative Medicine at the University of Colorado School of Medicine are part of a consortium awarded $3.8 million from the U.S. Department of Defense to move discoveries in stem cell-created skin grafts into the manufacturing stage, bringing further hope to victims of debilitating inherited skin diseases. The major grant for the Epidermolysis Bullosa (EB) iPS Cell Consortium, which includes research teams from the University of Colorado Anschutz Medical Campus. The study was published in Nature Communications.
According to a study, the researcher estimates that computing power can optimize the mobile emergency network, emergency medical service stations can ensure rapid emergency care for even greater swathes of the population and save money at the same time. The scope of the study, numerous possible distributions of emergency medical stations across the federal state of Lower Austria were calculated and compared using complex computer models.
New ways were found to provide emergency medical care to an even larger proportion of the population within a very short space of time with the same or fewer medical stations. The study was published recently in an International Journal of Medical Informatics. The consideration of extensive digital data on the existing road network, as well as population movements during the daytime, constituted an essential element of the computations.
Spaceflight introduces a combination of environmental stressors, including microgravity, ionizing radiation, changes in diet and altered atmospheric gas composition. In order to understand the impact of each environmental component on astronauts it is important to investigate potential influences in isolation. Ground control AEMs are engineered to match the spaceflight environment. There are limited studies examining the biological response invariably due to the configuration of AEM and vivarium housing.
Researchers investigated the effect of providing video information on anxiety and satisfaction in patients about to undergo spinal anesthesia. Providing sufficient information during a pre-anesthesia consultation can increase patient understanding and decrease anxiety related to spinal anesthesia. Surgical patients usually present with preoperative anxiety, which seems to begin as soon as the surgical procedure is planned. Anesthesia-related fear and its implications are an important source of this anxiety.
Is arthritis pain getting in the way of your fitness plans? That need not be the case. In fact, physical activity can be vital to your continued mobility, a new study suggests.
If you have osteoarthritis, participating in joint-friendly physical activity can improve your arthritis pain, function, mood, and quality of life.
Camilla Andersson, a radiology nurse, demonstrated in a recent dissertation at Uppsala University that improved information before undergoing PET/CT scanning can improve patients' experience of care