All news from Medical Toxicology

The Long and Short of CDK12 Mutations

Mutations in the BRCA1 and BRCA2 genes pose a serious risk for breast and ovarian cancer because they endanger the genomic stability of a cell by interfering with homologous recombination repair (HR), a key mechanism for accurately repairing harmful double-stranded breaks in DNA. Without the ability to use HR to fix double-stranded breaks, the cell is forced to resort to more error-prone—and thus more cancer-prone—forms of DNA repair

The Sounds Going Into Ears Process In Brains

You are walking along a busy city street. All around you are the sounds of subway trains, traffic, and music coming from storefronts. Suddenly, you realize one of the sounds you are hearing is someone speaking, and that you are listening in a different way as you pay attention to what they are saying.

First Responders Worried About Fentanyl OD

Every week it seems like there is a terrifying headline about how a drug bust seized enough fentanyl to kill the citizens of a city, state, or even a small country. (The Washington Post May 25, 2018; https://wapo.st/2IZV4rb.) Enough narcotics to kill 26,000,000 people?

Tumour-Vasculature Development After Radiotherapy

Despite recent technological advances in radiotherapy, challenges relating to tumor targeting, dose limitations, and tumor relapse and escape remain. Multiple strategies for targeting cancer cells, cancer stem cells (CSCs), tumor stroma, and tumor endothelial cells (ECs), as well as improving anti-tumor immune responses to increase tumor radiosensitivity, are being developed