All news from Anaesthesiology

Hypofibrinogenemia in Acute Trauma Patients and The Factors Affecting

Timely and aggressive hemostatic therapy is known as two major measures for improving the patients' survival. Considering the important role of fibrinogen depletion in the occurrence of acute traumatic coagulopathy, timely replacement of this blood product can affect trauma patients' outcome. Nevertheless, presently there are ongoing discussions about the time to start, the amount, and the ratio of blood products transfusion (particularly fibrinogen) in trauma patients.

RNAscope ISH Technology: Bio-Techne Expands Automation Capabilities

Bio-Techne has expanded the automation capabilities of its popular Advanced Cell Diagnostics (ACD)-branded RNAscope® in situ hybridization (ISH) technology with the launch of several new and updated assays. The developments increase both access to, and use of, RNAscope and improve overall robustness and ease-of-use.

The continued investment in automation builds on successful agreements with equipment providers and is driven by Bio-Techne’s desire to facilitate drug discovery and development via rapid, easy, and accurate gene expression detection and localization.

Knocking out p63 Gene Converts Scar Tissue into Muscle Tissue in the Heart

Following a heart attack, the parts of the heart muscle that die do not regenerate into new heart tissue and instead are replaced by scar tissue. Using rodent models, researchers at Baylor College of Medicine are looking for a means to genetically convert this scar tissue into muscle tissue at the cellular level, which could ultimately be a way to treat heart attack and heart failure patients. Their latest work was published in The Journal of Thoracic and Cardiovascular Surgery.

Validation of Generic all-oral DAA Regimens in HCV infection: Punjab, India

A large-scale study evaluating the feasibility of decentralized care and the provision of free direct-acting antiviral agents (DAAs) has reported high rates of cure among a population of almost 20,000 individuals completing treatment for hepatitis C virus (HCV) infection. The study conducted in Punjab, India, validated the efficacy and safety of generic all-oral DAA regimens delivered using a decentralized algorithm-based public health model.