Researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers. The research team showed switching off a gene called NF-κB1 caused the spontaneous development of stomach cancers, driven by chronic inflammation. The study also revealed that immunotherapy may prove to be a significant tool for treating stomach cancers that are driven by runaway inflammation, warranting further investigation. The study was published in the journal Immunity.
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The adult human heart cannot regenerate itself after injury, and the death of cardiac muscle cells, known as cardiomyocytes, irreversibly weakens the heart and limits its ability to pump blood. Heart disease is a major global health problem, myocardial infarction annually affects more than one million people in the U.S. alone, and there is still no effective treatment. The study was published in Nature Biomedical Engineering.
A study examines that researchers have used a new variant of super-resolution microscopy to visualize all the strands of a DNA-based nanostructure for the first time. The method promises to optimize the design of such structures for specific applications. The term 'DNA origami' refers to a method for the design and self-assembly of complex molecular structures with nanometer precision.The study was published in the journal Nature Communications.
According to a study, researchers used the model spinal cord injuries in rats for their purposes. As a result, it was found out that therapy by adipose-derived mesenchymal stem cells combined with fibrin matrix influences the restoration of motor functions. It also decreases the area of pathological cavities and reduces astroglial activation.
A study found that low amounts of the hormone could also be associated with chronic disease, even among men 40 years of age and younger. A male's total testosterone level may be linked to more than just sexual health and mass muscle preservation. By looking at data for men from a population level, it has become evident over time that chronic disease is on the rise in older males," says Mark Peterson. The study was published in Scientific Reports. They studied this relationship among testosterone, age and chronic disease.
According to a study, researchers examine that physician assistant (PAs), perform more skin biopsies per case of skin cancer diagnosed and diagnosis and dermatologists. The study was published in JAMA Dermatology.
A study estimates that an appropriate clinical setting, suspicion for acute aortic dissection should be raised when patients present with findings that have high specificity and high positive likelihood ratio (hypotension, pulse deficit, or neurologic deficit). The study was published in the Journal of Academic Emergency Medicine. Acute aortic dissection is a life?threatening condition due to a tear in the aortic wall. It is difficult to diagnose and if missed carries a significant mortality.
A new study showed that scientists developed the ability of bacteria to swap genetic material with each other can directly affect the emergence and spread of globally important infectious diseases. The study was published in Nature Communications.
Bariatric surgery has long yielded almost immediate health benefits for patients with type 2 diabetes, and new findings on the reasons for remission may be the key to developing drug alternatives to surgery.
According to the research, addition of ribavirin to direct-acting antiviral (DAA) treatment of hepatitis C virus (HCV) infection with mixed cryoglobulinemia (MC) proved advantageous to achieving an immunological response, with reduced serum cryocrit measured when sustained virologic response was achieved at 12 weeks (SVR12)
A study led by the University of Birmingham suggests a possible association between exposure to certain pollutants and an increased risk of so-called 'cot death' or sudden infant death syndrome (SIDS)