A study estimates that regional anaesthesia is safe and effective for lower limb orthopaedic surgery in a patient with renal tubular acidosis and hypokalemia. Renal tubular acidosis (RTA) with hypokalemia may precipitate acute respiratory failure and potentially fatal arrhythmias like ventricular fibrillation. Though there are random reports of respiratory failure needing mechanical ventilation and sudden death in patients with RTA and hypokalemia, the anaesthetic management of these patients has not been elucidated
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A new study suggests that cavity prevention programs with a combination of prevention strategies may be more effective than one alone for reducing tooth decay. The study was published in the journal BMC Oral Health.
According to a prospective study, researchers examine that most of the men with symptomatic Zika Virus (ZIKV) infections had the ZIKV genetic footprint in their semen for at least 30 days after symptom onset, but only 4% had an infectious virus. The study was published in the New England Journal of Medicine.
A study is to determine if serum concentrations correlated with cell surface expression. Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis includes features of lymphocyte dysfunction and exhaustion. Monoclonal antibodies targeting checkpoint molecules, such as programmed-death one protein (PD-1) and its ligand PD-L1, have shown success in stimulating the immune response in patients with cancer, and are being considered for future sepsis trials.
A study evaluates the biochemical indices during typical preseason training in wrestling athletes. Although regular training introduces the desired changes in athletes’ metabolism towards optimal final performance, literature is rarely focusing on the metabolic responses off-competition.
A study described a key signalling protein in Huntington's disease which shows deleterious effects on heart function, going beyond the disease's devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease. The study was published in Cell Reports.
According to a study, researchers estimated that women have previously experienced a heart attack have twice the risk of later myocardial ischemia provoked by mental stress when compared to men with a similar history. The samples of 418 individuals and found that impaired microvascular function in response to mental stress was responsible for the increased risk of ischemia, or obstructed blood flow to the heart, in women. The study was published in Circulation.
A study investigated the new microscope that captures the detailed 3-D movies of cells deep within living systems. Merging lattice light sheet microscopy with adaptive optics reveals the most detailed picture yet of subcellular dynamics in multicellular organisms. Our window into the cellular world just got a whole lot clearer. The study was published in the journal Science.
Researchers realized that humans evolved from a succession of primate ancestors, the public imagination has been focused on the inflexion point when those ancestors switched from ape-like shuffling to walking upright as we do today. Scientists have long been focused because our ancestors lived, hunted and evolved. A close examination of 3.6-million-year-old hominin footprints discovered in Laetoli, Tanzania, suggests our ancestors evolved the hallmark trait of extended leg, human-like bipedalism substantially earlier than previously thought.
The findings come from early-stage studies in both human cells and mice in which researchers tweaked the structure of an existing treatment for type 2 diabetes. Making tiny changes to existing diabetes treatments can alter how they interact with cells, and potentially make the medicines more effective. The study was published in the journal Nature Communications.
A retrospective study evaluates the association between marital status and T stage at the time of presentation with early-stage melanoma and the decision for sentinel lymph node biopsy (SLNB) in appropriate patients. There is a bonus to marriage for melanoma patients: They tend to be diagnosed in earlier more treatable stages than patients who are unmarried, widowed or divorced. The study was published in JAMA Dermatology.
A study determines that participating in a hot chilli pepper eating contest might have some unexpected consequences; their warning comes after a young man ended up in emergency care with excruciatingly painful episodic headaches after eating a 'Carolina Reaper,' the world's hottest chilli pepper. The study was published in the journal BMJ Case Reports.