All news from Anaesthesiology

Lower Limb Orthopedic Surgery Uses Regional Anesthesia

A study estimates that regional anaesthesia is safe and effective for lower limb orthopaedic surgery in a patient with renal tubular acidosis and hypokalemia. Renal tubular acidosis (RTA) with hypokalemia may precipitate acute respiratory failure and potentially fatal arrhythmias like ventricular fibrillation. Though there are random reports of respiratory failure needing mechanical ventilation and sudden death in patients with RTA and hypokalemia, the anaesthetic management of these patients has not been elucidated

To Compare Lymphocyte Subset Expression Of PD-1 Between Patients With Sepsis

A study is to determine if serum concentrations correlated with cell surface expression. Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis includes features of lymphocyte dysfunction and exhaustion. Monoclonal antibodies targeting checkpoint molecules, such as programmed-death one protein (PD-1) and its ligand PD-L1, have shown success in stimulating the immune response in patients with cancer, and are being considered for future sepsis trials.

A Key Signalling Protein Affect The Heart Function

A study described a key signalling protein in Huntington's disease which shows deleterious effects on heart function, going beyond the disease's devastating neurological impact. By adjusting protein levels affecting an important biological pathway, the researchers improved heart function in experimental animals, shedding light on the biology of this fatal disease. The study was published in Cell Reports.

Heart Attack Have Twice The Risk Of Lateral Myocardial Ischemia

According to a study, researchers estimated that women have previously experienced a heart attack have twice the risk of later myocardial ischemia provoked by mental stress when compared to men with a similar history. The samples of 418 individuals and found that impaired microvascular function in response to mental stress was responsible for the increased risk of ischemia, or obstructed blood flow to the heart, in women. The study was published in Circulation.

Old Hominin Footprints Compared With Ancestors Walking, Leg

Researchers realized that humans evolved from a succession of primate ancestors, the public imagination has been focused on the inflexion point when those ancestors switched from ape-like shuffling to walking upright as we do today. Scientists have long been focused because our ancestors lived, hunted and evolved. A close examination of 3.6-million-year-old hominin footprints discovered in Laetoli, Tanzania, suggests our ancestors evolved the hallmark trait of extended leg, human-like bipedalism substantially earlier than previously thought. 

Partners May Facilitate Early Detection Of Melanoma

A retrospective study evaluates the association between marital status and T stage at the time of presentation with early-stage melanoma and the decision for sentinel lymph node biopsy (SLNB) in appropriate patients. There is a bonus to marriage for melanoma patients: They tend to be diagnosed in earlier more treatable stages than patients who are unmarried, widowed or divorced. The study was published in JAMA Dermatology.