All news from Anaesthesiology

Cholera Outbreaks Seen In Haiti

According to campaigners accusing the global community of again failing the Caribbean nation. Haitians battling cholera blamed on United Nations peacekeepers are getting little support with only two percent of promised funds materializing, Haiti was free of cholera until 2010 when peacekeepers helping after a devastating earthquake that killed more than 250,000 people accidentally dumped infected sewage into a river. 

Couple Bridged Peptides Bind To Disease Targets

A study developed a new type of 'double-bridged peptide' that can be tailored to bind tightly to disease targets of interest. The peptides' highly efficient binding, combined with their small size and high stability make them ideal for drug therapies. Peptides are short chains of amino acids that can bind to proteins and change their function. They show a high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occurring peptides such as insulin, oxytocin, somatostatin and the antibiotics vancomycin or polymyxin B, are already successfully used like that.

Reprogramming Ordinary Cells Into Healthy Heart Muscle Cells

A study has created new healthy heart muscle cells within a patient's own ailing heartScientists have reprogrammed ordinary cells called fibroblasts into new and healthy heart muscle cells and recorded changes that appear to be necessary for this reprogramming. The reprogrammed ordinary cells called fibroblasts into new and healthy heart muscle cells and recorded changes that appear to be necessary for this reprogramming. The study was published in Cell Reports.

Cryo-electron Microscopy Images Reveals Drug-Target Sites

A study estimates that researchers discovered telomerase, an enzyme that lengthens chromosome ends and prevents them from fraying enough to kill a cell, speculation ran wild about its role in ageing and cancer, setting off a full-court press to produce drugs to activate or block the enzyme. Cryo-electron microscopy images reveal details of protein, RNA binding and possible drug-target sites. The study was published in the journal Nature.

Repeated Exposures To Anesthesia Affect Learning And Attention

According to a new study, researchers examined children with multiple exposures to anaesthesia before age three are more likely to develop adverse outcomes related to learning and attention. The study was published in Anesthesiology. They identified a cohort of children born between 1996 and 2000. Propensity matching selected children based on exposure or non-exposure to general anaesthesia before age 3. This identified 116 children multiply exposed, 457 singly exposed, and 463 unexposed children.

High And Low Levels Of Glycemic Control Lead Increased Mortality in Older Adults

Researchers determine that high and low levels of glycemic control and high HbA1c variability are associated with increased mortality in older people with diabetes. "In older populations, it is important to consider HbA1c values and trends as a health marker and not as a target," said Dr Angus Forbes. "The current system of care is biased toward lowering glycemic control, and this may lead to a lack of vigilance in relation to high-risk patients with lower or varying HbA1c levels." The study was published in The Lancet Diabetes and Endocrinology.

Burn Victim Saved By Skin Grafts From Identical Twin

A laboratory technician from the northern city of Amiens was given less than a one-percent chance of survival after a workplace accident in September 2016, when a can of chemicals he was holding exploded, setting him ablaze. The burns covered 95% of his body, sparing only his pubis, feet and face plus the prophetic tattoo, now framed by thick pink scars. Eighteen months later, thanks to skin grafts from his twin brother Eric.

Patients Stay In Hospital For More Than 72 Hours For Post TAVR

Researchers evaluate that for the first time, report a significant decline in the rates of delayed discharge; and identified independent predictors of both delayed and early discharge post TAVR. Patients who stay in the hospital for more than 72 hours when undergoing trans-femoral transcatheter aortic valve replacement (TF-TAVR) procedure may be associated with negative short and long-term outcomes. The study was presented as late-breaking clinical science at the Society for Cardiovascular Angiography and Interventions (SCAI) 2018 Scientific Sessions.