All news from Anaesthesiology

Unsafe Feces Disposal of Children in Rural Bangladesh

This study, among households with latrine access in rural Bangladesh, aimed to: (1) determine household characteristics associated with reported unsafe disposal of young children’s feces and observed human feces within the compound, (2) determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of reported child feces disposal practices compared to observed presence of human feces in the domestic environment, and (3) assess the association between unsafe child feces disposal and (i) fly presence and (ii) diarrhea among children <3 years living in the household.

Health Ministry Eases up on Stem Cell Therapy Regulation

The Indian Council of Medical Research has objected to amendments proposed by the Ministry of Health and Family Welfare to the Drugs and Cosmetics Rules, 1945 on the regulation of stem cells procedures.

The amendments seek to exclude certain kinds of processed stem cells, called minimally manipulated stem cells, from being defined as new drugs. Such an exclusion will man that these cells will not have to be tested in clinical trials for efficacy and safety before they receive market approval. If passed, these amendments may legitimize the use of unproven stem cell therapies in India. 

Baseball Pitchers: Limiting Throws Helps to Prevent Fatigue and Injuries

For high school baseball pitchers, limiting throws during a game helps to prevent fatigue and injuries. But nearly half the number of pitches—ones thrown during warm-ups and in the bullpen—are typically not counted, adding significantly to a pitcher's risk of injury, new findings by University of Florida Health researchers show.

Targeted Opioid Overdose Prevention Program Introduced

Pain management experts are making headway in reducing risks for opioid overdoses. After a targeted opioid overdose prevention program was introduced at an 18-bed inpatient rehabilitation unit, fewer patients were discharged with an opioid prescription, and more left with a naloxone kit or prescription.

Influenza Vaccine: Phase 2 Clinical Study Begins

A Phase 2 clinical trial of an investigational universal influenza vaccine intended to protect against multiple strains of the virus has begun in the U.S. The study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and is being conducted at four U.S. sites that are part of the NIAID-funded Vaccine and Treatment Evaluation Units (VTEUs).

The trial is testing an experimental vaccine called M-001 for safety and its ability to produce potentially broad protective immune responses, both on its own and when followed by a standard, licensed seasonal influenza vaccine.

Erythropoiesis: Different effects of G-CSF and EPO

The present study further investigated the differences between G-CSF and EPO on erythropoiesis. After mice had been treated with G-CSF and EPO, the erythropoiesis status in the BM and spleen were compared using flow cytometry.

The stimulation of early erythroid progenitor subsets and temporal regulation of erythroid progenitor mobilization were characterized. The mechanism of G-CSF promotion of erythropoiesis was also discussed.

Plazomicin Recommended for cUTI but Not BSI

The US Food and Drug Administration's (FDA's) Antimicrobial Drugs Advisory Committee recommended plazomicin (Achaogen Inc) for complicated urinary tract infections (cUTIs) but not for bloodstream infections (BSIs) in adults with limited or no treatment options.

A Key Element Of Brain Physiology Is Able To Function In Hostile Environment

During a stroke or an epileptic seizure, neurons in affected parts of the brain fire at an abnormally rapid rate. Using a powerful microscopy method called cryo-EM, biologists at Cold Spring Harbor Laboratory (CSHL) have discovered how one key element of brain physiology, a docking port for excitatory neurotransmitters called the NMDA receptor, is able to function in this hostile environment. One byproduct of this condition is that the pH of the brain drops markedly, rendering the local environment inhospitably acidic.