All news from Anaesthesiology

New Method To Target Skin Diseases Like Psoriasis

Research has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excessive cell division, known as hyperproliferation. Researchers demonstrated in mice that inhibiting glucose transport may be a safe and effective treatment for these diseases. The study was published in Nature Medicine.

New Drug Calms Violent Patients

Emergency Medicine Foundation (EMF) Australasia have conducted the world's first comparison of the standard sedative, midazolam, with droperidol in a prehospital setting. Australian paramedics are leading the world by introducing a new drug, droperidol, to quickly and safely calm violent patients fueled by alcohol and drugs. The study was published in the Journal of Prehospital Emergency Care.

Aortic Valve Endocarditis: A standardized Approach For Treatment

Guidelines support the use of both homografts and stentless bioprostheses in aortic valve endocarditis with paravalvular abscess formation. The choice of prosthesis depends on patient characteristics, technical considerations, and surgeon preferences.

In this illustrated series of sixteen patients with aortic valve endocarditis and complicating paravalvular abscess formation, researchers show that the use of stentless bioprostheses provides a more standardized surgical procedure that consists of thorough debridement, root replacement with reimplantation of the coronary arteries, and treatment of accompanying pathologies.

Pain Management Without Risk of Addiction, New Finding

Researchers at the University of Michigan have engineered a new compound that animal tests suggest could offer the pain-relieving properties of opioids such as morphine and oxycodone without the risk of addiction. With more than 100 Americans dying from opioid overdoses every day, there is an urgent need for drugs that offer strong pain-relieving properties without leading to addiction.

Anti-Alcoholism Drug Tested in Animal Models

Scientists at The University of Texas at Austin have successfully tested in animals a drug that, they say, may one day help block the withdrawal symptoms and cravings that incessantly coax people with alcoholism to drink. If eventually brought to market, it could help the more than 15 million Americans, and many more around the world who suffer from alcoholism stay sober.

Timing of Antibiotics: Vital Criteria for Surviving Sepsis

Sepsis is a common, life-threatening organ dysfunction driven by a dysregulated host response to infection. Outcomes have improved over the years in line with a focus on intravenous fluids, appropriate antimicrobials, and other supportive measures, but for septic shock, mortality remains at 30% to 50%.

The 2017 Surviving Sepsis Campaign guidelines endorse a focus on the rapidity of treatment once sepsis has been identified, with a strong recommendation for the administration of antimicrobial drugs within 1 hour; however, the quality of the supporting evidence is evaluated as moderate.

Detection of Breast Lymphedema

A new study suggests testing for small changes in the flow of lymph fluids after breast cancer surgery can spot the start of a painful swelling known as lymphedema before it becomes hard to treat.