A study aimed to assess whether behavior, glutamate receptor gene expression, and dendritic structure in the hippocampus are altered in mice after early exposure to 16O radiation in mice. Exposure to 16O significantly reduced the expression of Nr1 and GluR1 in the hippocampus and modulated spine morphology in the dentate gyrus and cornu Ammon 1 within the hippocampus. The pathogenesis of this injury is unknown but may involve glutamate receptors or modifications to the dendritic structure and/or dendritic spine density and morphology.
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According to researchers, patients undergoing same-day surgery, low functional health literacy is associated with poorer postoperative recovery and lower health-related quality of life. "Patients in today's health care system are expected to take part and to be engaged in their own care," Dr. Maria Halleberg-Nyman of Orebro University and colleagues note. "Consequently, they have to be able to read and understand health instructions on how to manage their own recovery at home."
Researchers assessed the roles of the nucleolus in major physiological functions including stress response, development, and aging. Over the past few years, researchers have been piecing together an unexpected link between aging and an organelle typically known as the cell's ribosome factory. The connections between the nucleolus and age-related pathways such as those associated with dietary restriction. The study was published in the journal Cell Biology.
A new study has develped the cochlear implants, where it helps to identify a friend's voice so you can follow her amusing anecdote over the din of a cocktail party. Using both ears to hear increases speech recognition and improves sound localization.
Improved tools are under development for determining the causes of death in settings where medical examinations or post-mortem autopsies are not routinely conducted. The population-based approach, namely verbal autopsy using standardized interviews, including signs, symptoms, and circumstances leading to death, conducted with the bereaved family, are becoming the best alternative in the more affluent parts of the world.
Researchers from the Albert Einstein College of Medicine in New York have discovered that a signaling protein elevated in patients with acute myeloid leukemia (AML) plays a much wider role in the disease than previously thought.
The study, which will be published in the Journal of Experimental Medicine, raises hopes that current efforts to target this signaling protein could be a successful strategy to treat AML and other blood cancers.
A scalable method of generating universal 'off-the-shelf' natural killer (NK) cells for cancer immunotherapies has been devised by A*STAR researchers. Their technique could ensure that future NK cell-based cancer treatments can be used for most patients.
If you've had a minor stroke or a transient ischemic stroke (TIA), taking the clot-preventing drug clopidogrel along with aspirin may lower your risk of having a major stroke within the next 90 days, according to new research published in The New England Journal of Medicine.
By analyzing reported physical activity levels over time in more than 11,000 American adults, Johns Hopkins Medicine researchers conclude that increasing physical activity to recommended levels over as few as six years in middle age is associated with a significantly decreased risk of heart failure, a condition that affects an estimated 5 million to 6 million Americans. The same analysis found that as little as six years without physical activity in middle age was linked to an increased risk of the disorder.
The multi-target small molecule anticancer drug nintedanib shows promising effectiveness in stopping the growth of human malignant pleural mesothelioma, a fatal thoracic tumor, in preclinical models, according to a new study published jointly by researchers in Austria, Germany and Hungary.
An automated system that uses robots has been designed to rapidly produce human mini-organs derived from stem cells. Researchers at the University of Washington School of Medicine in Seattle developed the new system. A report describing the new technique will be published online in the journal Cell Stem Cell.
Older patients on uninterrupted oral anticoagulation are more likely than younger patients to experience bleeding during catheter ablation for atrial fibrillation, regardless of anticoagulant type, researchers in Japan say.