All news from Anaesthesiology

Investigation Of Monkeypox Outbreak In Congo

A study inspected that 10 suspected cases of monkeypox in Likouala Department, Republic of the Congo, triggered an investigation and response in March 2017 that included community education and surveillance strengthening. Increasing numbers of outbreaks suggest that monkeypox virus is becoming a more prevalent human pathogen. Diverse approaches are necessary for disease control and prevention.

Practices For Nurse Facilitate Pediatric Otolaryngology To Caregivers

Researchers strategic use of advanced practice nurses to resolve patient triage issues can speed clinician response time to clinically-relevant phone calls in a high-volume pediatric otolaryngology practice. Over the course of 40 months, 4,839 clinically relevant phone calls were received, an average of 128 calls per month. The baseline mean was 101 monthly calls and the post-intervention mean was 130 calls. The study was published in JAMA Otolaryngology-Head and Neck Surgery,

Impairments Caused By Short Sleep Duration Without Extended Wakefullness

Researchers team has isolated the impacts of short sleep and extended wakefulness on vigilant performance. Millions of individuals obtain insufficient sleep on a daily basis, which can lead to impaired performance and other adverse physiological outcomes. To what extent these impairments are caused by the short sleep duration or corresponding extended wakefulness was unknown. The study was published in PNAS.

Association Of Psychosis Risk With Both Behavioral And Striatal Dysfunction

Researchers found evidence that boosting how well people at risk for psychosis learn from positive and negative feedback could potentially keep psychosis at bay. Psychotic disorders often are severe and involve extreme symptoms such as delusions or hallucinations in which people lose their sense of reality. The team also found that brain scans using functional magnetic resonance imaging, coupled with behavioral measures, could provide markers for the diagnosis of psychosis risk. The study was published in the  Schizophrenia Bulletin. 

Amino Acid Mechanism Sensing By T-Box Riboswitch

A new study examines that a common but little-understood bacterial switch that cuts off protein production before it begins. A new discovery that points to potential new antibiotic medicines,  Many gram-positive bacteria use T-box riboswitches to regulate the production of proteins that utilize amino acids, the basic building blocks of all proteins. The study was published in Nature Communications.


Tiny Biological Particles Are Seen Microscopically

Researchers have developed tiny valves that enable individual nanoparticles in liquids to be separated and sorted. The valves can be used for a very broad range of tiny particles, including individual metal and semiconductor nanoparticles, virus particles, liposomes and larger biomolecules such as antibodies. Newly-developed nanovalves allow the flow of individual nanoparticles in liquids to be controlled in tiny channels. This is of interest for lab-on-a-chip applications such as in materials science and biomedicine.

Sublingual Form Of Buprenorphine For The Treatment Of Severe Pain

The researcher estimates that US Food and Drug Administration (FDA) advisory committee has voted overwhelmingly against approving a sublingual form of buprenorphine for the treatment of moderate-to-severe acute pain. The joint meeting of the Anesthetic and Analgesic Drug Products Advisory Committee and the Drug Safety and Risk Management Advisory Committee voted 18-1 against the approval of Buvaya, a spray form of buprenorphine an opioid that is primarily used for medication-assisted treatment.

Small Cluster Of Cells In Human Embryo Dominate Fate Of Other Cells

Scientists have shown that a small cluster of cells in the human embryo dictates the fate of other embryonic cells. The discovery of this developmental 'organizer' could advance research into any human diseases, and it suggests we have more in common with birds than meets the eye. The factors that shape the destiny of a cell, like that of a fully formed person, remain something of a mystery. The study was published in the journal Nature.

Determination Of Simulated Microgravity Affects Muscle Cells In Space

The molecular mechanisms involved in myogenic differentiation are relatively well-known. Myogenic differentiation is regulated by the sequential activation of the basic helix-loop-helix myogenic regulatory transcription factors (MRFs), and biomechanical signals play an important role in the regulation of myogenesis. Astronauts go through many physiological changes during their time in spaceflight, including lower muscle mass and slower muscle development. Similar symptoms can occur in the muscles of people on Earth's surface, too. In fact, it could affect everyone to some extent later in life. The study was published in npj Microgravity.