All news from Paediatrics

Disease Research: Bioengineered Human Cardiac Models Spur Disruptive Innovation

Thrombosis-on-a-chip, vasculature-on-a-chip and engineered models of human cardiac fibrosis are just a few of the new technologies revolutionizing research into human cardiovascular disease—a condition responsible for 17 million deaths per annum globally. A new study published in the journal Biomaterials by bioengineering scientists from the University of Toronto, proposes a new paradigm for research into cardiovascular diseases.

HSV-1 qPCR in the Diagnosis of Lower Respiratory Tract Infections

Researchers aimed to determine a quantitative herpes simplex virus (HSV) DNA threshold in lower respiratory tract specimens that correlates with positive viral culture and clinical outcomes. In this study, researchers determined a quantitative threshold of HSV DNA in lower respiratory tract specimens that correlated with positive viral culture and clinical outcome.

Researchers also investigated the utility of quantitative polymerase chain reaction (qPCR) for a housekeeping gene to account for differences in the cellularity of the lower respiratory tract specimens. Finally, we evaluated the relationship between the HSV viral load and clinically relevant outcomes.