All news from Anaesthesiology

Lung Cancer: Promising Results With New Airway Transplantation Technique

De novo generation of cartilage within cryopreserved aortic allografts has been observed recently. This process originated from the recipient cells, which was observed in animal models.

Moreover, remaining viable matrix cells have been identified to play a critical role in the regenerative process as a way to release proangiogenic, chemoattractant, pro-inflammatory or pro-immunomodulatory cytokines, and growth factors.

This prospective study was designed to evaluate the feasibility of airway bioengineering using stented cryopreserved aortic allografts as biological matrices.

Effectiveness of Pembrolizumab in Non-Small Cell Lung Cancer

Most patients with advanced non-small cell lung cancer (NSCLC) can now avoid having chemotherapy as a first-line treatment after a large, randomized trial showed that immunotherapy with the programmed cell death ligand 1 (PD-L1) blocker pembrolizumab (Keytruda, Merck) is effective even in patients with minimal PD-L1 expression.

New Programmed Shape-Morphing Scaffolds Enabled Facile 3-D Endothelialization

Recently, a research team led by Dr. DU Xuemin at the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences created a new shape-morphing scaffold, enabling programmed deformation from a 2-D planar cell-laden structure to a well-defined 3-D tubular shape, which facilitated the facile 3-D endothelialization of small-diameter vascular grafts.

RFID Chips Aid in Tracking Biological Samples

Researchers want to use radio frequency identification (RFID) chips for keeping track of organoids, samples of human tissue that mimic pieces of organs and are grown from stem cells. The organoids the researchers embedded with RFID chips functioned normally and withstood extreme conditions, suggesting that they could be a useful way to organize and identify the large quantities of organoids needed in experimental situations.

Mutations in the Ebola Virus Makona Genome and Pathogenecity

Early during the West African Ebola epidemic, scientists speculated that the genetic diversity of the Makona strain of virus (EBOV-Makona) would result in more severe disease and more transmissibility than prior strains. However, scientists have determined that certain mutations stabilized early during the epidemic and did not alter Ebola disease presentation or outcome. Their work offers evidence to support previous findings that the diversity of EBOV-Makona did not significantly impact the course of the disease.