All news from Anaesthesiology

Lung Cancer: Development of New Immune Therapies

Protein kinases regulate nearly all processes in cells. If the function of these enzymes is disrupted, often cancer will develop. In particular certain types of deregulated mitogen-activated protein kinases (MAPKs) are believed to be the cause of various types of cancer.

Illegal Online Marketing of Unapproved Opioids Contributed to the Nation's Opioid Crisis

The U.S. Food and Drug Administration today announced that it has warned nine online networks, operating a total of 53 websites, that they must stop illegally marketing potentially dangerous, unapproved and misbranded versions of opioid medications, including tramadol and oxycodone. Companies who fail to correct the violations, as outlined in the warning letters, may be subject to enforcement action, including product seizure or injunction.

Phase 1/2 study of RSV Vaccine Began By Pfizer

Pfizer Inc. announced that it has started a Phase 1/2 trial of its respiratory syncytial virus (RSV) vaccine candidate in healthy adult volunteers. RSV is a common respiratory virus that affects the lungs and airways, with significant impact on young children and older adults. The highest risk of severe outcome from RSV occurs in the first months of life.  

Rise in Prep Uptake Among Gay Men

Some parts of Australia show an increase in uptake of pills that can prevent contracting HIV but also a sharp drop in condom use among men having sex with men. This was found in a major study and is cause for concern.

Secrets of HIV's Persistence Unraveled

Thanks to advances in the development of anti-retroviral therapy (ART), patients with HIV are living longer than ever before. And yet, even in patients on very effective, long-term ART, HIV persists, requiring patients to take antiviral medication life-long. It's thought that the virus establishes a "persistent reservoir" of infected cells that can survive almost indefinitely.

A new study by investigators at Brigham and Women's Hospital explores how the virus gets this foothold, identifying cellular survival programs that become activated in infected cells, and providing a potential target for future therapy. Their results are published this week in Immunity.