MiNA Therapeutics, the pioneer in RNA activation (RNAa) therapeutics, today announced preliminary results from its ongoing Phase I study of small activating RNA (saRNA) candidate MTL-CEBPA in advanced liver cancer. In the study, MTL-CEBPA was generally well tolerated in patients with both healthy and impaired liver function and provided evidence of anti-tumor activity. MTL-CEBPA was also found to mediate RNAa activity in white blood cells.
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Researchers have developed a novel computational tool named BigSCale to analyze millions of single cells simultaneously. Their work analyzed 1.3 million cells and unraveled an unprecedented heterogeneity in rare cell populations during mouse brain development.
The University of New Mexico Comprehensive Cancer Center has joined the other 69 cancer centers designated by the National Cancer Institute to issue a statement urging increased vaccination for human papillomavirus.
Macrophages, large white blood cells that engulf and destroy potential pathogens, harbor active viral reserves that appear to play a key role in impaired learning and memory in mice infected with a rodent version of HIV. Chao-Jiang Gu et al. present these new findings in PLOS Pathogens.
Immunization with beneficial bacteria can have long-lasting anti-inflammatory effects on the brain, making it more resilient to the physical and behavioral effects of stress, according to new research by University of Colorado Boulder scientists.
As word came over the radio that a Sherpa had been struck on the head by a falling rock high on Everest, the three doctors at base camp jumped into action, fully aware that saving him would be a life-or-death race against the unpredictable mountain.
Autistic Spectrum Disorder (ASD) is a multi-factorial disorder. There is no one cause of ASD. The most prominent risk factor is genetics. Studies by the All India Institute of Medical Sciences (AIIMS) reveal that one in 89 children aged between two and nine years have been diagnosed with autism in India.
Zika virus is an arbovirus transmitted by the Aedes aegypti mosquito, but it can also be transmitted by sexual contact and blood transfusion. Adult patients infected with Zika usually present only mild symptoms over a few days, such as rashes, conjunctivitis, arthralgia and mild fever.
The new study, titled "Acute and chronic neurological consequences of early-life Zika virus infection in mice," is published in the renowned journal Science Translational Medicine, and offers new hope for the public health crisis that has arisen in countries affected by Zika virus.
About 25% of Americans experience acute insomnia each year, but about 75% of these individuals recover without developing persistent poor sleep or chronic insomnia, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania which was presented at SLEEP 2018, the 32nd Annual Meeting of the Associated Professional Sleep Societies LLC (APSS).
A congressional panel grilled top executives from the U.S. Olympic Committee and the governing bodies of four sports on whether they have done enough to protect athletes from sexual abuse.
Respiratory doctors and scientists from six continents have warned of the dangers posed to children and adolescents by e-cigarettes. They are calling for an immediate ban on flavorings and on marketing e-cigarettes as lower risk alternatives to children and adolescents.