All news from Cardiology

Oral Cavity Cancer: Lymph Node Ratio Could Predict Survival

Five years after diagnosis, only 40% of patients with locally-advanced oral cavity cancer will still be alive. The question is who is likely to live and who is likely to die? The answer to this question could not only help patients better predict the course of their disease, but could help doctors choose the most appropriate post-surgical treatments – patients at highest risk could receive the most aggressive combinations of radiation and chemotherapy.

Metabolic Syndrome: Systems Biology Brings Tailor-made Approach

About a quarter of all adults have metabolic syndrome; a syndrome whose most well-known symptoms are obesity, high blood pressure and poor cholesterol levels. Eating differently and exercising more is the general advice for this condition, but that is not the whole story. Ph.D. candidates Yvonne Rozendaal and Fianne Sips developed systems biology models that describe the processes of metabolic syndrome in the body in detail.

First Evolutionary Study to Explore Origins of Walking Cavefish

A new research collaboration begins an unprecedented study of walking cavefish to better understand the "fin-to-limb" transition that enabled the first vertebrates to walk on land more than 350 million years ago.

This new research collaboration is set to launch the first evolutionary study of the unique pelvic structure and walking mechanics of the waterfall-climbing blind cavefish, or Cryptotora thamicola — the only living species of fish known capable of walking on land with a similar motion as four-limbed vertebrates, or tetrapods, which include mammals, reptiles and amphibians.

Reduces Breast Cancer Radiotherapy Side Effects

A practice-changing new clinical trial has been found to reduce long-term radiotherapy side effects in women with breast cancer. The large-scale clinical trial, conducted by The Institute of Cancer Research and the University of Cambridge, has shown that targeting or reducing the dose of radiotherapy for women with breast cancer after surgery can substantially reduce the side effects they experience in the long-term.

Human Dendritic Cell ER Stress Response Reduces T cell Alloreactivity

Acute graft- vs. host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent GVHD that impairs monocyte-derived dendritic cell (moDC) alloactivation of T cells, yet preserves graft- vs.-leukemia (GVL). Exceeding endoplasmic reticulum (ER) capacity results in a spliced form of X-box binding protein-1 (XBP-1s).