Using data from a nationwide survey that represents 11 million women with heart and blood vessel diseases, Johns Hopkins Medicine researchers say women continue to report significant disparities in the care they receive compared with men. And the root problem, many women say, is that health care providers don’t listen to or respect them.
All news from Cardiology
Five years after diagnosis, only 40% of patients with locally-advanced oral cavity cancer will still be alive. The question is who is likely to live and who is likely to die? The answer to this question could not only help patients better predict the course of their disease, but could help doctors choose the most appropriate post-surgical treatments – patients at highest risk could receive the most aggressive combinations of radiation and chemotherapy.
About a quarter of all adults have metabolic syndrome; a syndrome whose most well-known symptoms are obesity, high blood pressure and poor cholesterol levels. Eating differently and exercising more is the general advice for this condition, but that is not the whole story. Ph.D. candidates Yvonne Rozendaal and Fianne Sips developed systems biology models that describe the processes of metabolic syndrome in the body in detail.
Many people first became familiar with DNA testing through its use in the OJ Simpson murder trial in 1994. Now, 24 years later, there have been two dramatic advances in the capability of forensic genetics that mark the start of a new era.
Magnetic resonance imaging (MRI) scans of people watching the same clip from a dramatic film show that holistic thinkers all have similar brain responses to the scene, whereas analytical thinkers respond differently to each other.
A new research collaboration begins an unprecedented study of walking cavefish to better understand the "fin-to-limb" transition that enabled the first vertebrates to walk on land more than 350 million years ago.
This new research collaboration is set to launch the first evolutionary study of the unique pelvic structure and walking mechanics of the waterfall-climbing blind cavefish, or Cryptotora thamicola — the only living species of fish known capable of walking on land with a similar motion as four-limbed vertebrates, or tetrapods, which include mammals, reptiles and amphibians.
The skin is our largest organ, and, among other things, it protects against mechanical impacts. To ensure this protection, skin cells have to be connected especially closely.
A practice-changing new clinical trial has been found to reduce long-term radiotherapy side effects in women with breast cancer. The large-scale clinical trial, conducted by The Institute of Cancer Research and the University of Cambridge, has shown that targeting or reducing the dose of radiotherapy for women with breast cancer after surgery can substantially reduce the side effects they experience in the long-term.
The variable clinical presentation of malignant hyperthermia (MH), a disorder of calcium signalling, hinders its diagnosis and management. Diagnosis relies on the caffeine-halothane contracture test, measuring contraction forces upon exposure of muscle to caffeine or halothane (FC and FH, respectively).
The US Food and Drug Administration (FDA) has approved ravulizumab (Ultomiris, Alexion Pharmaceuticals) injection, the first and only long-acting C5 complement inhibitor for adults with paroxysmal nocturnal hemoglobinuria(PNH), a rare blood disease.
Acute graft- vs. host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent GVHD that impairs monocyte-derived dendritic cell (moDC) alloactivation of T cells, yet preserves graft- vs.-leukemia (GVL). Exceeding endoplasmic reticulum (ER) capacity results in a spliced form of X-box binding protein-1 (XBP-1s).
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with various clinical manifestations. MicroRNAs (miRNAs) and immunometabolism are recognized as key elements in SLE pathogenesis; However, the relationship between miRNAs and peripheral blood mononuclear cells (PBMCs) and metabolism in SLE remains unclear.