All news from Anaesthesiology

Loss Of Muscle At Microgravity

Scientists have identified DNA methylation as a crucial mediator of muscle loss at microgravity as well as at normal gravity. Researchers have demonstrated that the underlying mechanism of muscle loss under space-like conditions is also prevalent in the presence of gravity. The study was published in Microgravity.

Unique Way Of Seeing The Human Anatomy

A study determines human anatomy is a cornerstone of medical and nursing education. They are able to gain hands-on experience by working with human cadavers and then manipulating finely detailed, computer-generated, three-dimensional renditions of the human body and its parts in a special laboratory.

Cancer Prevention Through HPV Vaccination

Parents ranked cancer prevention as the most compelling reason health care providers can give for recommending the human papillomavirus (HPV) vaccine, according to a survey led by University of North Carolina Lineberger Comprehensive Cancer Center researchers.

Structure Of Telomerase Seen By Cryo-electron Microscopy

Researchers observed the structures of TEN and TRAP, and how they interact with each other and with the telomerase RNA. Many mutations that scientists attributed to the TEN region, in fact, disrupt TEN's interaction with TRAP. The study was published in Cell.

Cancer, aging-related diseases, and other illnesses are closely tied to an important enzyme called "telomerase," whose catalytic core where most of its activity occurs can now be seen in near atomic resolution. At each step, they zoom in closer and see more and more details, and can now begin to deduce not just what the enzyme looks like, but also how it functions. Knowing that may lead to the development of new drugs that target specific parts of the enzyme.

Body's Circadian Clocks Affecting The Sleep

The circadian rhythm has gotten more notice recently, scientists who discovered this day-night cycle. But popular knowledge focuses on how the circadian rhythm affects how we sleep, ignoring many of the other ways this cycle runs our lives. They cannot fall asleep and wake up at the same time, nor sleep and do heavy-duty digesting. The body needs time to rest and repair, and so it works on a set clock called the circadian rhythm.

Thyroid Hormone Dysfunction Increased Risk Of Gestational Diabetes

Thyroid dysfunction during the first half of pregnancy is associated with an increased risk of gestational diabetes, adding weight to the argument for thyroid screening among pregnant women. Specifically, the longitudinal study suggests that a higher level of free triiodothyronine (fT3) may be involved in the pathophysiology of gestational diabetes, which might be because of de novo synthesis or increased conversion of free thyroxine (fT4) to T3.

The study was published online in the Journal of Clinical Endocrinology & Metabolism, They are the first ones to show that the fT3:fT4 ratio is significantly related to an elevated risk of gestational diabetes, that "this builds on previous work showing a relationship between the ratio and other markers of glucose metabolism."

Neuropeptide Involved In Transmitting Itch Signal To Brain In Eczema

A study showed that a particular neuropeptide associated with transmitting itch signals in mice with atopic dermatitis. The work sheds further light on the pathways involved in transmitting itch sensations from the peripheral (skin) to the central (spinal cord) nervous system.

The signal goes from neuronal projections in the skin through the dorsal root ganglia (DRG) – which are clusters of sensory cells located at the root of the spinal nerves then to the spinal cord. They are interested in finding out how the portion of this pathway from DRG to spinal cord works in terms of signaling itchiness in chronic skin disease.

Does Mental Stress Cause Vision Loss?

According to a study, the researcher examines that Persistent psychological stress, which is widely recognized as a consequence of vision loss, is also a major contributor to its development and progression. The study was published in the EPMA Journal.

Clinical practice implications of this finding include a recommendation to improve the clinician-patient relationship and provide stress-reduction treatments and psychological counseling to interrupt the vicious cycle of stress and progressive vision loss.