End-of-life health care spending in the United States may not be the low-hanging fruit it is often thought to be, according to a predictive modeling study recently published in Science.
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A DNA-sensing enzyme forms droplets that act as tiny bioreactors creating molecules to stimulate innate immunity, the body's first response to infection, UT Southwestern researchers report.
A new study reveals that individuals younger than 50 years of age who are diagnosed with rectal cancer do not experience an overall survival benefit from currently recommended treatments.
Researchers examined the responses of intestinal mucosal barrier functions to simulated weightlessness, by using the hindlimb unloading rats model. Exposure to microgravity or weightlessness leads to various adaptive and pathophysiological alterations in digestive structures and physiology.
Compared with normal controls, simulated weightlessness damaged the intestinal villi and structural integrity of tight junctions, up-regulated the expression of pro-apoptotic protein Bax while down-regulated the expression of anti-apoptotic protein Bcl-2, thus improved the intestinal permeability. It could also influence intestinal microbiota composition with the expansion of Bacteroidetes and a decrease of Firmicutes.
Researchers have found evidence that suggests evolutionary changes in anatomy would have made walking more economical without reducing the utility of muscles for climbing in early hominins. The study was published in Proceedings of the National Academy of Sciences, the group describes studying bones and fossils from human ancestors and how they fit together to determine their walking and climbing abilities.
The study shows changes in anatomy would have made walking easier without reducing muscles for climbing in early hominins. In early human ancestors first began walking upright remains a topic of debate among scientists, and research continues to find the answer.
In this new effort, the researchers took another look at conventional ideas suggesting that the first hominins to walk upright likely did so extremely awkwardly, as they retained physical features that would allow them to escape enemies by climbing trees.
Researchers have now structurally characterized late stages in the assembly of the human small ribosomal subunit, yielding detailed insights into their maturation principles. Ribosomes are the cell's protein factories. The study was published in the journal Nature.
Researchers have been able to use cryo-electron microscopy, to reveal the detailed structure of the common herpes virus. Researchers at the University of Glasgow used the cutting-edge technology to reveal, in high resolution, the biological mechanisms the herpes virus uses to infect people. The study was published in PLOS Biology.
Researchers have conducted that general anesthesia may not be as general as we might think. In fact, the research suggests that parts of our consciousness stay "awake" during the procedure. Consciousness fully lost during anesthesia. The answer may surprise anesthesiologists and patients alike. Consciousness appears to be more persistent than we think. The study was published in the journal Anesthesiology.
Researchers have shown that seriously ill and frail hospitalized patients are frequently subjected to unnecessary, invasive procedures that do not enhance the quality of life. Surveys amongst seriously ill hospitalized patients have identified the better end of life planning as an area of potential improvement for hospitals
The level of communication between patient and physician can make a monumental difference, specifically in the case of seriously ill hospitalized patients. Researchers at the University of Minnesota have found a way to better identify these patients with the hopes of the better facilitating "end-of-life" or specialized conversations and care.
A study determines that especially at longer follow-up times, overweight and obesity are associated with chronic disease risks for survivors of moderate to severe traumatic brain injury (TBI). The study was published in the Journal of Head Trauma Rehabilitation (JHTR).
Examine the prevalence of weight classifications and factors related to obesity/overweight among persons 1 to 25 years following traumatic brain injury (TBI) using the Traumatic Brain Injury Model Systems national database.
According to a new study, researchers examine that a new drug could restore hearing by 'turning on' genes that keep vital hair cells in the inner ear alive. The study shows that a particular kind of genetic deafness, called DFNA27, can be reversed using a molecular drug that 'acts like a switch' for deafness. The study was published in Cell.
New drug could restore hearing by 'turning on' genes that keep hair cells alive
1. Scientists discover faulty DFNA27 gene can be fixed by introducing a drug
2. They were able to partially restore hearing in mice
3. Similar approaches might work for the inherited progressive hearing loss
4. Deafness has genetic causes in more than 50% of people and is incurable
A new study has shown that despite excellent glycemic control and low glycemic variability throughout their pregnancies, women with type 1 diabetes tended to give birth to infants who were large for gestational age. To examine trimester-specific associations among glycemic variability, fetal growth, and birthweight in pregnancies with type 1 diabetes mellitus (Type 1 DM).
Researchers documented elevated fetal weight and abdominal circumference percentages throughout the pregnancies that were consistent with accelerated prenatal growth. The study was published in Diabetes Technology & Therapeutics (DTT).