All news from Anaesthesiology

Biochemical Interaction Of Kinase Enzyme

Researchers reveal that curcumin, a naturally occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. Through x-ray crystallography and kinase-inhibitor specificity profiling, researchers reveal that curcumin, a naturally occurring chemical compound found in the spice turmeric, binds to the kinase enzyme dual-specificity tyrosine-regulated kinase 2 (DYRK2) at the atomic level. The study was published in the Proceedings of the National Academy of Sciences,

This previously unreported biochemical interaction of curcumin leads to inhibition of DYRK2 that impairs cell proliferation and reduces the cancer burden. But before turning to curcumin or turmeric supplements. They report that curcumin binds to and inhibits DYRK2 leading to the impediment of the proteasome the cellular protein machinery that destroys unneeded or damaged proteins in cells, which in turn reduces cancer in mice.

Crime Scenes: Bloodstains Used To Determine Victim's Age

From the spatter analysis made famous in the TV show Dexter to the frequent DNA profiling of CSI and the real cases covered in the FBI Files, blood tests are ubiquitous in forensic science. Now, researchers report that a new blood test, which could be performed at a crime scene, could help determine the age of a suspect or victim within just an hour.

Men Would Have Have Less Favorable Attitudes Toward Palliative Care

According to a study, researchers hypothesized that men and those with lower levels of educational attainment would have less favorable attitudes toward palliative care. Men with advanced cancer are 30% less likely than women to consider palliative care.

Fighting Cancer

Researchers believe the findings reflect social norms about gender roles as well as widespread messages in the media and society about "fighting" cancer. Often men see themselves as the family protector. When struck with a serious illness they usually want to be cast as a "fighter" or a "warrior," and may view palliative care as giving up.

The analysis accounted for other factors such as aggressiveness of cancer, age, race, and financial status, but gender was the only factor that significantly influenced preference for palliative care. The study was published in the Journal of Pain and Symptom Management.

Post-Traumatic Stress Disorder And Cardiovascular Diseases

According to a study, researchers determined whether post-traumatic stress disorder (PTSD) is a risk factor for myocardial infarction (MI) and stroke, beyond the expected effects from recognized cardiovascular risk factors and depression. Post-traumatic stress disorder (PTSD) may increase the long-term risk for stroke and heart attack. The study was published in the journal Circulation: Cardiovascular Quality and Outcomes.

M. tuberculosis Escapes Death in Macrophages

The bacteria that cause the devastating disease tuberculosis have the ability to escape destruction and grow after they are engulfed by lung macrophages, the immune cells that are supposed to destroy pathogens. Now researchers at the University of Alabama at Birmingham have described key biochemical steps between the bacteria Mycobacterium tuberculosis and the macrophage responsible for that ability.

NASA Astronauts Workouts In Space

A new study showed that NASA Astronauts should keep a track of their health by workouts and maintain their arm muscles and moves in the space station.

1. NASA astronauts have to maintain killer arm muscles to move and work in space.

2. They exercise for two hours per day on the International Space Station.

3. You can test your own interplanetary strength with a few of Astronaut Peggy Whitson's favorite training exercises.

Method To Treat Blood Vessel Damage in Diabetes

A study showed the evidence in diabetes, both the tightly woven endothelial cells that line our blood vessels and the powerhouses that drive those cells start to come apart as early steps in the destruction of our vasculature.

Levels of the enzyme PDIA1, which enables a healthy homeostasis of endothelial cells as well as the production of new blood vessels, decrease in diabetes, while the activity of Drp1, a key regulator of fission regulated by PDIA1. The study was published in the journal Cell Reports.

High Rate Of Skin Cancer In Military Personnel

According to a study, researchers conducted an extensive review of skin cancer risks for US military personnel to inform preventive education, diagnosis, and treatment efforts to better protect these individuals from future skin cancer development. There is an increased risk for skin cancer among U.S. active duty service members and veterans. The study was published in the June issue of the Journal of the American Academy of Dermatology.