All news from Anaesthesiology

Protein Complex Identifies Patients Develop Resistance To Anti-Cancer Drugs

Researchers have identified a protein complex that might explain why some cancer patients treated with the revolutionary new anti-cancer drugs known as PARP inhibitors develop resistance to their medication. They showed that Shieldin so called because it shields the ends of broken DNA regulates DNA repair and could be a useful marker for identifying which patients are likely to respond poorly to PARP inhibitors. The study was published in Nature Cell Biology.

Enzymes Bifurcation Revealed By Mass Spectrometry

Scientists have used the atomic resolution structural models of proteins from X-ray crystallography, nuclear magnetic resonance spectroscopy, and more recently cryo-electron microscopy. However, not all proteins relent to structural analyses using these approaches, and as the depth of knowledge increases, additional data elucidating a mechanistic understanding of protein function is desired. 

Parents Are Worried That Their Child Being Allergic To Anesthesia

The study showed that parents are worried about their child being allergic to anesthesia. Unfortunately, many people have been told that they are allergic to certain drugs when they had a reaction that was not a true allergy.

Body's Immune System

The medical definition of an allergy is an abnormal response of the body to an otherwise harmless substance. When your body’s immune system detects a foreign substance that it deems harmful, it manufactures antibodies to attack and neutralize it. This can manifest as hives, itching, and watery eyes or anaphylaxis, a severe reaction that can include critical drops in blood pressure, difficulty breathing, and possibly even swelling of the throat.

Palliative Care Is Improving In The United States

According to a new study, researchers determined that the quality of care at the end of life has improved in the United States since 2000, with fewer deaths occurring in acute care hospitals and more occurring at home or in hospice. The study was published online in JAMA.

Palliative Care Patients

Fewer end-of-life patients are being transferred to hospitals for "burdensome care" for things like dehydration and infections, the study found, and use of the intensive care unit (ICU) in the last month of life, which had increased until 2009, has stabilized.

Predicting Mortality Rates In Sepsis Patients With PIRO Score

Mortality in patients with intra-abdominal sepsis remains high. Recognition and classification of patients with sepsis are challenging; about 70% of critical care specialists find the existing definitions confusing and not clinically useful.

To assess the usefulness of the predisposition, infection/injury, response, organ dysfunction (PIRO) concept in surgical intensive care patients with severe sepsis or septic shock due to an intra-abdominal source.

Human Bone Cells Can Be Affected By Microgravity

Researchers have suggested that normal physiological processes, such as the functional integrity of muscles and bone mass, can be affected by microgravity during spaceflight. During the lifespan, bone not only develops as a structure designed specifically for mechanical tasks but also adapts for efficiency. 

Life on Earth developed under the influence of normal gravity (1g). The lack of weight-bearing forces makes microgravity an ideal physical stimulus to evaluate bone cell responses. One of the most serious problems induced by long-term weightlessness is a bone mineral loss.

Relationship Between Low Iodine Intake And Hearing Loss

Researchers conducted a study of US teens with the lowest levels of urinary iodine were five-times more likely to have hearing loss associated with speech comprehension than their peers with higher iodine levels.

This relationship has important public health implications because youth with hearing impairment experience academic difficulties, have behavioral problems, and demonstrate lower performance in oral language compared with peers with normal hearing. The study was published online in JAMA Otolaryngology-Head & Neck Surgery.

Glucotypes Reveal New Patterns Of Glucose Dysregulation

According to a study, researchers developed a device that keeps extra-close tabs on the ups and downs of blood glucose levels reveals that most people see only a partial picture of the sugar circulating in their blood. It turns out that the level of sugar in an individual's blood, especially in individuals who are considered healthy, fluctuates more than traditional means of monitoring, like the one-and-done finger-prick method, would have us believe.

Often, these fluctuations come in the form of "spikes," or a rapid increase in the amount of sugar in the blood, after eating specific foods most commonly, carbohydrates. There are lots of folks running around with their glucose levels spiking, and they don't even know it. The study was published online in PLOS Biology.

Tanning Products Able To Reduce Risk Of Skin Cancer

Many advertisements, articles, and reports make bold statements regarding sunless tanning products sprays, ointments, creams, foams, or lotions that promise tan skin without the increased risk of skin cancer that goes along with outdoor sunbathing or indoor tanning. 

Few studies have investigated this topic and Health, to question whether he should recommend sunless tanners to his patients. In the study "Characteristics and Skin Cancer Risk Behaviors of Adult Sunless Tanners in the United States." The study was published in JAMA Dermatology.

Lifesaving Techniques To Save Choking During Emergency Case

Researchers found a technique, a well-known technique has resurfaced a decades-old debate about whether to slap or squeeze. Sen. Claire McCaskill (D-Mo.) found herself in a dangerous situation last month when she started choking during a Democratic members' luncheon. Sen. Joe Manchin (D-W.Va.) swooped in, grabbed her around the middle and squeezed her, performing the Heimlich maneuver to dislodge the food.