All news from Anaesthesiology

Combination Of Drugs Receives Opinion For Treating Melanoma

Pierre Fabre today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending approval of BRAFTOVI® (encorafenib) and MEKTOVI® (binimetinib) in combination for the treatment of adult patients with unresectable or metastatic melanoma with a BRAFV600 mutation. 

The CHMP recommendation will now be reviewed by the European Commission (EC), which has the authority to approve medicines for the European Union (EU). "We are delighted to be one step closer to bringing BRAFTOVI and MEKTOVI to patients with advanced BRAF-mutant melanoma in Europe. If the European Commission approves BRAFTOVI and MEKTOVI, this will be a new treatment option for these patients who currently have a challenging prognosis.

New Forms in The Circadian Clock

A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation. From the heart and lungs that propel our blood to our rumbling stomachs at lunchtime and a feeling of tiredness in the evening, our bodies keep steady rhythms day in and day out.

This 'circadian clock' is a series of tightly controlled cycles of specific amounts of proteins that make us either sleepy or wakeful. It has recently attracted public attention with the 2017 Nobel Prize for Physiology or Medicine, but numerous aspects of the clock's functions or how it regulates our health remain a mystery.

Microdosing Psychedelic Might Ease Anxiety

Researchers reveal fascinating insights into how people use small doses of psychedelic drugs for therapeutic effects. Microdosing is the practice of taking drugs like LSD or psilocybin (the key ingredient in "magic mushrooms") in amounts too small to produce a "high" but are anecdotally reported to quell anxiety, boost mood, or improve focus and creativity.

Because the drugs are illegal in many jurisdictions, microdosing remains an underground practice and, until recently, was not subject to close scientific investigation. That has changed with a new study that examines how and why people microdose and the reported effects of the practice. According to study co-author Thomas Anderson, it is the first study of its kind.

Device Implanted To Control High Blood Pressure

A Long Island patient has become the first in the Northeast to have a small, experimental device implanted in the upper thigh to control aggressively high blood pressure, doctors at the Northwell Health system said.

The novel treatment involves a tiny experimental device called the ROX Coupler, which is slightly smaller than a paper clip but is designed to take on the titanic task of controlling a form of hypertension that defies attempts to lower blood pressure by using drugs, diet, and exercise.

Medical History Online Important in Healthcare in India

Our data is constantly being collected and harvested—a breach of privacy most recently uncovered through political plots. One can’t Google a product or service without it showing up later, baiting you through advertisements and sponsored posts. I understand why the idea of data being stored insidiously has become a scary, almost dystopic thought. But I’ve always felt is that one sector underutilizes data and for the worst possible reason.

Positive Opinion for Treating Cystic Fibrosis

Vertex Pharmaceuticals (Europe) Limited announced that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for SYMKEVI® (tezacaftor/ivacaftor) in a combination regimen with ivacaftor (KALYDECO®) for the treatment of people with cystic fibrosis (CF) aged 12 and older.

Those who either have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, or one copy of the F508del mutation and a copy of one of the following 14 mutations in which the CFTR protein shows residual activity: P67L, R117C, L206W, R352Q, A455E, D579G, 711+3A→G, S945L, S977F, R1070W, D1152H, 2789+5G→A, 3272-26A→G, and 3849+10kbC→T.

OpenSim: Powerful, Accurate Simulations for Movement Research

An open-source movement simulator that has already helped solve problems in medicine, paleontology, and animal locomotion has been expanded and improved, according to a new publication in the open-access journal PLOS Computational Biology.  The software, called OpenSim, has been developed by a team and the new paper reviews the software’s wide range of applications and describes the improvements that can increase its utility even further.