All news from Anaesthesiology

Gene Controls Tissue In Bone Marrow

In an unexpected discovery, UCLA researchers have found that a gene is previously known to control human metabolism also controls the equilibrium of bone and fat in bone marrow as well as how an adult stem cell expresses its final cell type.

The findings could lead to a better understanding of the disruption of the bone-to-fat ratio in bone marrow as well as its health consequences and also point to the gene as a promising therapeutic target in the treatment of osteoporosis and skeletal aging. The study was published online in the journal Cell Stem Cell.

Enzyme Use Aminoacid For Catalysis

Researchers have created a new enzyme with an unnatural amino acid as its active center. They made the enzyme by modifying an antibiotic binding protein which normally acts as a bacterial transcription factor. Further modifications of the reactive site can create different enzymes for use in chemical synthesis. The study of the new enzyme was published in Nature Chemistry.

Scanning Electron Microscopy Used In Biomedical Research

Researchers find solutions to the issues that are faced daily in medicine by combining biology with mathematics, physics, or chemistry. These research fields address various problems through the development of bionic parts, implants, medical devices and imaging equipment, along with tissue engineering. It involves extremely delicate and very detailed work that requires very high precision.

Scanning electron microscopy (SEM) imaging is a robust tool to study such details at the nanoscale and to push the analyzes further. SEMs are highly versatile instruments that are shown to be particularly useful in various biomedical research fields, ranging from orthodontics to bone grafts and tissue engineering.

Local Anesthetic Does Not Reduce Opioid Use

A study reveals that the local anesthetic drug, liposomal bupivacaine, did not reduce in-hospital opioid prescriptions or opioid-related complications in patients who received the drug during total knee replacement surgery as part of a multimodal approach to managing postsurgical pain. The study was published in Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

Practice For End-Of-Life Is Legal Everywhere

The study shows cancer had spread everywhere, from her colon to her spine, her liver, her adrenal glands and one of her lungs. Eventually, it penetrated her brain. No medication made the pain bearable. A woman who had been generous and good-humored turned into someone hardly recognizable to her loving family: paranoid, snarling, violent.

California’s aid-in-dying law, authorizing doctors to prescribe lethal drugs to certain terminally ill patients, was still two years from going into effect in 2016. But Ms. Martin did have one alternative to the agonizing death she feared: palliative sedation.