All news from Anaesthesiology

Human Cell Ageing Reversed By New Compounds

In a new study, researchers have developed key aspects of the aging of human cells can be reversed by new compounds developed at the University of Exeter. In a laboratory study of endothelial cells – which line the inside of blood vessels researchers tested compounds designed to target mitochondria (the "power stations" of cells).

In the samples used in the study, the number of senescent cells (older cells that have deteriorated and stopped dividing) was reduced by up to 50%. The Exeter team also identified two splicing factors (a component of cells) that play a key role in when and how endothelial cells become senescent. The study was published in the journal Aging.

Super-Resolution Microscopy Imaging Of Telomere Structure

Researchers have discovered the role of macromolecular telomere structure in chromosome end protein, with implications for conditions ranging from cancer to aging and heart disease. Telomeres are DNA segments at the ends of every human chromosome. As we age, telomere length naturally decreases. Over the course of a lifetime, telomere shortening instructs aging cells to stop dividing.