All news from Endocrinology

PCOS Patients With Insulin Resistance Decreased Cortisol Levels

A new study has shown that polycystic ovary syndrome (PCOS) patients with insulin resistance (IR) have decreased oxidation of cortisol and defects of insulin signaling in the endometrium.

In addition, local cortisol elevation, derived from the reduction of 11β-hydroxysteroid dehydrogenases (11β-HSD) 2, may influence the development of endometrial IR through the inhibition of the insulin signaling pathway via induction of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression in endometrial epithelial cells (EECs).

Melanoma Can Predict Future Cancers

According to a new study, people who have multiple incidences of a common type of skin cancer are at an increased risk of developing a range of other cancers. Skin cancer is by far the most common cancer; there are a number of types, the most common being basal cell carcinoma. There are millions of diagnoses each year in the United States.

Our skin is regularly bombarded by ultraviolet light, which damages DNA and can eventually lead to cancer. The study was published in the journal JCI Insight. In our cells, there is a range of proteins whose job it is to repair this type of damage.

New Insights on Brain discovery, Aging's Terrible Toll on the Mind Blocked

Aging vessels connecting the brain and the immune system play critical roles in both Alzheimer's disease and the decline in cognitive ability that comes with time, new research reveals. By improving the function of the lymphatic vessels, scientists have dramatically enhanced aged mice's ability to learn and improved their memories. The work may provide doctors an entirely new path to treat or prevent Alzheimer's disease, age-related memory loss and other diseases.

Circadian Rhythm Could Help To Lose Weight, Sleep Better And Live Longer

A study examined that a lifestyle change based around our circadian rhythms to improve our health, beginning with when to eat, when to sleep, and when to get some exercise. LOSE weight, become more energetic and sleep well every night. Bold promises outlined on the cover of The Circadian Code. 

The term circadian is derived from the Latin ‘circa diem’, meaning ‘approximately a day’. This isn’t a diet, it’s a lifestyle change and one that involves relatively small adjustments to daily routines. It begins with knowing when to eat (as opposed to what) and when to turn off the lights, exercise, maximize sleep and brain function. 

Viral Hepatitis and its ABCDE

Millions of people across the globe, including in our own backyard, are living with a viral hepatitis infection and may not even know it. Experts at Baylor College of Medicine say awareness and diagnosis is the first step to taking control and making changes to either prevent or treat this potentially deadly infection.

Drug-Resistant Bacteria: Rescuing Antibiotics' Effectiveness

Bacteria — especially Gram-negative strains — are becoming increasingly resistant to current antibiotic drugs, and the development of new classes of antibiotics has slowed.

Faced with these challenges, investigators are studying the potential of combination therapy, in which two or more drugs are used together to increase or restore the efficacy of both drugs against a resistant bacterial pathogen.

Now new research indicates that such synergy may work even when bacteria become resistant to colistin, which is considered a treatment agent of last resort.

Bipolar Individuals, Depressive Symptoms Negatively Affect Sexual Function

A recent study has found that in bipolar individuals, depressive and manic symptoms appear to negatively affect sexual functioning. Using the Diagnostic and Statistical Manual of Mental Disorders, researchers conducted structured interviews with 60 participants with bipolar disorders and 60 age-matched controls. Depressive and manic symptoms were evaluated. Sexual function was evaluated using the international indices of erectile function (IIEF) and female sexual function index (FSFI).

Physical Activity Modifies The Risk Of AF In Obese People

Atrial fibrillation(AF) is an irregular and often rapid heart rate that can increase the risk of stroke, heart failure, and other heart-related complications. It's more common in older people, and as it happens, in people who are obese. But new research suggests that exercise can have a moderating effect on the risk of developing this problem.

The risk of atrial fibrillation was lower the more physically active a person was. This turned out to be especially true for people with obesity. The study was published in the European Journal of Preventive Cardiology.