All news from Transfusion Medicine

Hi-Tech Orthopedic Care Tested Crucially

In a consulting room in Togo's capital, Lome, Geraldo Emmanuel handicapped since birth six years ago waits patiently on a bed while a digital scan is taken of his right leg. The child walks on his toes so I'm scanning his leg so we can make him an orthotic using a 3D printer," said Enyonam Ekpoh, from Togo's national orthopedic device and physiotherapy center (CNAO).

Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival

A study showed that injection of neuropeptide vasoactive intestinal peptide (VIP) directly into the eye of mice enhanced corneal graft survival. VIP produced other benefits, including acceleration of endothelial wound closure, protection of corneal endothelial cells (CEnCs), and improved corneal graft clarity.

If proven successful in clinical studies, this novel approach may help alleviate visual loss in many patients with corneal disease. The study was published in the American Journal of PathologyThe successful outcome of corneal transplantation mainly relies on the density and function of CEnCs, which keep the graft transparent.

To improve the outcomes of corneal transplantation, various strategies have been employed to prevent immune-mediated graft rejection or enhance survival and function of CEnCs. However, an effective method has remained elusive so far.

Breast Cancer Patients Lack Cardiac Monitoring

Less than half of the women with early breast cancer underwent recommended cardiac monitoring after receiving trastuzumab, a drug that has redefined the treatment of HER2-positive disease but also carries a higher risk for cardiotoxicity.

The rate of heart failure (HF) was 8.3% in women who took trastuzumab-based chemotherapy vs 2.7% in those who did not (P < .001). Rates were roughly halved in patients using vs not using anthracyclines an older class of cancer drugs also associated with cardiotoxicity (4.6% vs 4.0%; P = .048).

The study was published in JACC Cardiovascular Interventions.