All news from Tropical Medicine

Statistical Method: Gene-to-gene Interactions Linked with Cancer Analyzed

Researchers have developed another novel statistical method for evaluating gene-to-gene interactions associated with cancer and other complex diseases. The Additive-Additive 9 Interaction (AA9int) method is described in a paper published in Bioinformatics. "This method can identify combinations of genetic variants for predicting cancer risk and prognosis," notes Dr. Lin, who is also the paper's lead author.

Mepolizumab for COPD, FDA Panel Against the Recommendation

The US Food and Drug Administration's (FDA's) Pulmonary-Allergy Drugs Advisory Committee voted overwhelmingly not to recommend (no-16, yes-3) mepolizumab (Nucala, GlaxoSmithKline) "as add-on treatment to inhaled corticosteroid-based maintenance treatment for the reduction of exacerbations in patients with chronic obstructive pulmonary disease (COPD) guided by blood eosinophil counts."

Importance of Dental Health Detailed in Tongue Microbiome Research

Elderly individuals with fewer teeth, poor dental hygiene, and more cavities constantly ingest more dysbiotic microbiota, which could be harmful to their respiratory health, according to new research published in the journal mSphere. The findings come from a large, population-based study that identified variations in the tongue microbiota among community-dwelling elderly adults in Japan.