All news from Anaesthesiology

Peptide Based Screen Detects Mutations Affecting Protein-Protein Interactions

The seizures typically begin in the first months of life. It often takes years, however, before those suffering from the rare glucose transporter type 1 (Glut1) deficiency syndrome obtain a correct diagnosis. If the disorder goes untreated, affected children experience developmental delay and frequently have neurological problems.

Various defects in one gene underlie the syndrome. They cause the Glut1 protein to lose its function in the cell membrane: the protein no longer transports glucose from the blood into the brain. The study was published in the current issue of the journal Cell

Circadian Metabolism Reveals Communication Between Organs And Tissue

Researchers have identified a system of communication networks that exist among organs and tissues that regulate metabolism. Findings from their study provide, for the first time, a detailed "atlas" illustrating how the body creates and uses energy, and how imbalances in the networks may impact overall health.

The study was published in the journal Cell. The research reveals the highly coordinated, multi-tissue metabolism underlying the body's circadian rhythms and examines how disruptions in these rhythms such as those caused by high-fat diets induce misalignment among the network clocks and can trigger inflammation, which has been linked to major diseases and can affect lifespan.

Life Events Contribute The Risk For Depression

A study in adolescent girls reports that recent life events impact depressive symptoms differently, depending on how the brain responds to winning and losing. A strong brain response to winning boosted the beneficial impact of positive experiences on symptoms, whereas a strong response to losing enhanced the detrimental impact of negative experiences on symptoms. The study was published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Reverb? Couples The Circadian Clock to Hepatic Glucocorticoid Action

The researcher found that out of 752 genes which regulate lungs in mice, 230 genes work only in the day and only 197 at night. And in the liver, where doctors have long thought that steroids are influential for many side effects, 1,702 genes regulate the organ in the day and a mere 299 at night in mice.

The research could one day have important implications on the way steroids one of the most common drugs in medicine are prescribed. The study was published in the Journal of Clinical Investigation.